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RAD51 135G>C polymorphism and breast cancer risk: a meta-analysis

  • Epidemiology
  • Published:
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Abstract

Mutations in RAD51 gene are believed to be associated with elevated breast cancer risk. However, several case–control studies focusing on the association between RAD51 135G>C and breast cancer risk failed to achieve consensus. To clarify the effect of RAD51 135G>C polymorphism on breast cancer, a meta-analysis was performed. By searching PubMed and EMBASE, a total of 14 case–control studies, containing 12,183 cases and 10,183 controls, were included. The strength of association between RAD51 135G>C polymorphism and breast cancer risk was assessed by odds ratio (OR) with the corresponding 95% confidence interval (95% CI). When all the eligible studies were pooled into the meta-analysis, an elevated cancer risk was revealed in additive model (OR, 1.34; 95% CI, 1.01–1.78; P = 0.044) and recessive model (OR, 1.37; 95% CI, 1.03–1.82; P = 0.032). In subgroup analyses by ethnicity, BRCA1/2 mutation status, and family history, a significant association was found only among BRCA2 mutation carriers (additive model: OR, 4.92; 95% CI, 1.11–21.83; P = 0.036; recessive model: OR, 4.88; 95% CI, 1.10–21.67; P = 0.037). Sensitivity analysis did not perturb the results. In conclusion, this meta-analysis suggests that RAD51 variant 135C homozygote is associated with elevated breast cancer risk among BRCA2 mutation carriers.

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Authors and Affiliations

  1. Department of Respiration, Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai, 200433, People’s Republic of China

    Guo-Wu Zhou & Qiang Li

  2. Department of Oncology, Changhai Hospital, Second Military Medical University, Shanghai, 200433, People’s Republic of China

    Jia Hu

  3. The Health Department of Guard Bureau under PLA General Staff Department, Beijing, 100017, People’s Republic of China

    Xu-Dong Peng

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  1. Guo-Wu Zhou
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  2. Jia Hu
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  4. Qiang Li
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Correspondence to Qiang Li.

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G.-W. Zhou and J. Hu equally contributed to this study.

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Zhou, GW., Hu, J., Peng, XD. et al. RAD51 135G>C polymorphism and breast cancer risk: a meta-analysis. Breast Cancer Res Treat 125, 529–535 (2011). https://doi.org/10.1007/s10549-010-1031-8

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