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Polymorphisms of the BRCA2 and RAD51 Genes in Breast Cancer

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Summary

We performed a case-control study (150 cases and 150 controls) to test the association between three polymorphisms in BRCA2 and RAD51 genes and breast cancer risk. Genotypes were determined in DNA from blood cells by PCR–RFLP. Cancer occurrence was strongly associated with the BRCA2 Met/1915Thr homozygous polymorphic variants, whereas heterozygous variant was associated with significant reduction in breast cancer risk. Gene-gene interaction between the BRCA2-Met1915Thr Thr/Thr and BRCA2-Met784Val Met/Met homozygous variants increased the risk. Therefore, the Met1915Thr polymorphism in the BRCA2 gene may be considered as an independent marker of breast cancer.

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Authors and Affiliations

  1. Department of Molecular Genetics, University of Lodz, Lodz, Poland

    Tomasz Sliwinski, Renata Krupa, Ireneusz Majsterek & Janusz Blasiak

  2. N. Copernicus Hospital, Lodz, Poland

    Jan Rykala, Agnieszka Kolacinska & Zbigniew Morawiec

  3. Department of Clinical Pharmacology, Medical University of Lodz, Lodz, Poland

    Jozef Drzewoski

  4. Polish Mother’s Memorial Hospital, Lodz, Poland

    Marek Zadrozny

Authors
  1. Tomasz Sliwinski
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  2. Renata Krupa
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  3. Ireneusz Majsterek
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  4. Jan Rykala
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  5. Agnieszka Kolacinska
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  6. Zbigniew Morawiec
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  7. Jozef Drzewoski
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  8. Marek Zadrozny
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  9. Janusz Blasiak
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Corresponding author

Correspondence to Janusz Blasiak.

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Sliwinski, T., Krupa, R., Majsterek, I. et al. Polymorphisms of the BRCA2 and RAD51 Genes in Breast Cancer. Breast Cancer Res Treat 94, 105–109 (2005). https://doi.org/10.1007/s10549-005-0672-5

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  • DOI: https://doi.org/10.1007/s10549-005-0672-5

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