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The association between TA-repeat polymorphism in the promoter region of UGT1A1 and breast cancer risk: a meta-analysis

  • Epidemiology
  • Published:
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Abstract

Uridine diphospho-glucuronosyltransferase 1A1 (UGT1A1) plays an important role in breast cancer development. To date, many publications have evaluated the correlation between UGT1A1 TA-repeat polymorphism and breast cancer risk. However, the results remain inconclusive. In order to resolve this conflict, a meta-analysis was performed by searching Medline, PubMed, and ISI Web of Knowledge databases. Seven studies including 5,746 cases and 8,365 controls were collected for UGT1A1 TA-repeat polymorphism. The strength of association between UGT1A1 TA-repeat polymorphism and breast cancer risk was assessed by calculating crude ORs with 95% CIs. Overall, no significant associations between UGT1A1 TA-repeat polymorphism and breast cancer susceptibility were found. In the stratified analysis by ethnicity and source of controls, significant associations were only observed for 6/6 versus 7/7 (OR = 0.88; 95% CI: 0.77–0.99; P = 0.425 for heterogeneity) in Caucasians, but no in other genetic models. In conclusion, this meta-analysis suggests that UGT1A1 A(TA)7TAA allele is a potential risk factor for breast cancer in Caucasians.

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Acknowledgments

This study was supported by national 973 programs of China grants 2004CB518605, the national 863 project of China grants 2006AA020501, and the national key sci-tech special project of China grants 2008ZX10002-020.

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Authors and Affiliations

  1. State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, People’s Republic of China

    Lei Yao, Lu Yu, Xia-Jia Yu & Long Yu

  2. Institutes of Biomedical Sciences, Fudan University, Shanghai, People’s Republic of China

    Long Yu

  3. Department of Medical Oncology, Cancer Hospital, Fudan University, Shanghai, People’s Republic of China

    Li-Xin Qiu

  4. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China

    Li-Xin Qiu

  5. Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering, School of Life Sciences, Fudan University, Shanghai, People’s Republic of China

    Lei Yao, Zhen Yang & Yang Zhong

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  1. Lei Yao
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  2. Li-Xin Qiu
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  3. Lu Yu
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  4. Zhen Yang
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  5. Xia-Jia Yu
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  6. Yang Zhong
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  7. Long Yu
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Correspondence to Long Yu.

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Lei Yao and Li-Xin Qiu have contributed equally to this work and should be considered as co-first authors.

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Yao, L., Qiu, LX., Yu, L. et al. The association between TA-repeat polymorphism in the promoter region of UGT1A1 and breast cancer risk: a meta-analysis. Breast Cancer Res Treat 122, 879–882 (2010). https://doi.org/10.1007/s10549-010-0742-1

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  • DOI: https://doi.org/10.1007/s10549-010-0742-1

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