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TNFα −308 G/A polymorphism is associated with breast cancer risk: a meta-analysis involving 10,184 cases and 12,911 controls

  • Epidemiology
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Abstract

Tumor necrosis factor α (TNFα) is a pleiotropic cytokine which can regulate a wide variety of cellular responses. Low concentrations of TNFα seem to increase tumor growth and progression. The −308 G/A polymorphism in TNFα has been implicated in breast cancer risk but the published data remain inconclusive. In order to derive a more precise estimation of the relationship, a meta-analysis was performed by searching PubMed, Web of Science, ScienceDirect, EBSCO, CNKI, and Chinese Biomedicine Database. 11 studies including 10,184 cases and 12,911 controls were collected for TNFα −308 G/A polymorphism. Crude ORs with 95% CIs were used to assess the strength of association between the TNFα −308 G/A polymorphism and breast cancer risk. The pooled ORs were performed for codominant model (GG versus AA; GA versus AA), dominant model (GG + GA versus AA), recessive model (GG versus GA + AA), and G allele versus A allele, respectively. Overall, significantly elevated breast cancer risk was found for recessive model (OR = 1.10, 95% CI = 1.04–1.17) and for G allele versus A allele (OR = 1.08, 95% CI = 1.02–1.14). In the subgroup analysis by ethnicity, significantly increased risks were also found among Caucasians for recessive model and for G allele versus A allele (for recessive model: OR = 1.10, 95% CI = 1.04–1.17; for G allele versus A allele: OR = 1.09, 95% CI = 1.03–1.14). However, no significant associations were found among Asians for all genetic models. In conclusion, this meta-analysis suggests that the TNFα −308 G allele is a risk factor for developing breast cancer, especially for Caucasians.

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Acknowledgments

This study was supported by national 973 programs of China Grants 2004CB518605, the national 863 project of China Grants 2006AA020501, and the national key sci-tech special project of China Grants 2008ZX10002-020.

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Authors and Affiliations

  1. State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China

    Fang Fang, Lei Yao, Xiao Jia Yu, Lu Yu, Qi Wu & Long Yu

  2. Institutes of Biomedical Sciences, Fudan University, Shanghai, China

    Long Yu

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Correspondence to Long Yu.

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Fang, F., Yao, L., Yu, X.J. et al. TNFα −308 G/A polymorphism is associated with breast cancer risk: a meta-analysis involving 10,184 cases and 12,911 controls. Breast Cancer Res Treat 122, 267–271 (2010). https://doi.org/10.1007/s10549-009-0698-1

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  • DOI: https://doi.org/10.1007/s10549-009-0698-1

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