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Estrogen Metabolizing Polymorphisms and Breast Cancer Risk Among Older White Women

  • Epidemiology
  • Published:
Breast Cancer Research and Treatment Aims and scope Submit manuscript

Summary

Objective. To investigate breast cancer risk according to metabolizing genes polymorphisms in older women.

Methods. A subset (43.8%) of 4248 older, white women from the Study of Osteoporotic Fractures (SOF) were genotyped for the catechol-O-methyltransferase (COMT) Val108Met polymorphism and the CYP1A1*2C locus. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations between genotypes and breast cancer while controlling for potential confounders.

Results. During a mean follow up of 12.4 years, 252 women (5.9%) developed breast cancer. The HR (95% CI) for breast cancer was 1.24 (0.87–1.75) for COMTVal/Met and 1.35 (0.93–1.97) for COMTMet/Met. No interactions with lifestyle and reproductive factors were found. The HR associated with the CYP1A1*2C Val allele was 0.80 (0.46, 1.39) with little evidence for interactions with lifestyle or reproductive factors.

 Conclusions. Among older white women, neither the COMT Val108/158Met polymorphism nor the CYP1A*2C Val allele plays a major role in breast cancer risk either alone or in combination with lifestyle and reproductive factors.

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Authors and Affiliations

  1. Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, USA

    Francesmary Modugno, Joseph M. Zmuda & Jane A. Cauley

  2. University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA

    Francesmary Modugno, Douglas Potter & Chao Cai

  3. Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA

    Douglas Potter

  4. Department of Medicine, University of California (San Francisco), San Francisco, CA, USA

    Elad Ziv & Katie L. Stone

  5. Director of Clinical Research, San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, CA, USA

    Steven R. Cummings

  6. Axys Pharmaceuticals, Inc. , Southwest Fisheries Science Center, San Francisco, La Jolla, CA, USA

    Phillip A. Morin

  7. Roche Molecular Systems, Pleasanton, CA, USA

    Deborah Greene

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  1. Francesmary Modugno
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  2. Joseph M. Zmuda
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Correspondence to Francesmary Modugno.

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Modugno, F., Zmuda, J.M., Potter, D. et al. Estrogen Metabolizing Polymorphisms and Breast Cancer Risk Among Older White Women. Breast Cancer Res Treat 93, 261–270 (2005). https://doi.org/10.1007/s10549-005-5347-8

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