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Efficacy of weekly paclitaxel in patients with docetaxel-resistant metastatic breast cancer

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Summary

Background. Partial cross-resistance to paclitaxel and docetaxel has been demonstrated in pre-clinical studies.

Patients and methods. We retrospectively evaluated the efficacy of weekly paclitaxel 80 mg/m2 in 82 patients with docetaxel-resisitant metastatic breast cancer. Docetaxel resistance was classified into primary resistance, defined as progressive disease while receiving docetaxel, and secondary resistance, defined as progression after achievement of a documented clinical response to docetaxel. Secondary resistance was subclassified according to the interval between the final infusion of docetaxel and the start of weekly paclitaxel into: (1) short interval, ≦120 days, and (2) long interval, >120 days.

Results. The response rate of the 82 patients was 19.5% (95% confidence interval, 10.8–27.9%). The response rate according to the docetaxel resistance category was: primary resistance (n=24), 8.3%; secondary resistance (n=58), 24.1% (short interval [n=39], 17.9%, and long interval, [n=19], 36.8%). The differences in response rates among the three categories were statistically significant (p=0.0247, Cochran–Mantel–Haenszel test). The interval between from the final docetaxel infusion and disease progression were predictors for response of weekly paclitaxel.

Conclusion. Weekly paclitaxel is modestly effective and safe in docetaxel-resistant metastatic breast cancer patients. However, weekly paclitaxel should not be recommended for primary resistance patients with docetaxel.

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Abbreviations

MBC:

metastatic breast cancer

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Authors and Affiliations

  1. Breast and Medical Oncology Division, Department of Medical Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan

    Kan Yonemori, Noriyuki Katsumata, Koji Matsumoto, Tsutomu Kouno, Shinya Tokunaga, Yasuhiro Yamanaka, Chikako Shimizu, Masashi Ando & Yasuhiro Fujiwara

  2. Division of Biostatistics, Kitasato University Graduate School, 5-9-1, Shirokane, Minato-ku, Tokyo, Japan

    Hajime Uno & Masahiro Takeuchi

Authors
  1. Kan Yonemori
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  2. Noriyuki Katsumata
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  3. Hajime Uno
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  4. Koji Matsumoto
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  5. Tsutomu Kouno
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  6. Shinya Tokunaga
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  7. Yasuhiro Yamanaka
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  8. Chikako Shimizu
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  9. Masashi Ando
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  10. Masahiro Takeuchi
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  11. Yasuhiro Fujiwara
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Correspondence to Yasuhiro Fujiwara.

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Yonemori, K., Katsumata, N., Uno, H. et al. Efficacy of weekly paclitaxel in patients with docetaxel-resistant metastatic breast cancer. Breast Cancer Res Treat 89, 237–241 (2005). https://doi.org/10.1007/s10549-004-2184-0

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  • DOI: https://doi.org/10.1007/s10549-004-2184-0

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