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TMS Orientation for NIRS-Functional Motor Mapping

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Summary

Functional near-infrared spectroscopic imaging (NIRS imaging) has the potential to elucidate the relationship between neuronal activity and oxygenation responses. However, its signal specificity to the functional cortex is sometimes spoiled by its rough spatial resolution. In this study we incorporated transcranial magnetic stimulation (TMS) motor mapping into an NIRS imaging study to enhance spatial specificity to the functional cortex. Distinctive biphasic responses in the cortical oxygenation status were observed in the center of the primary motor cortex during a motor task. The early response phase, occurring within 1 to 3 seconds after task initiation, represents a cortical deoxygenation which consists of a significant increase in deoxygenated hemoglobin concentration (HbR) and a nonsignificant decreasing tendency in oxygenated hemoglobin concentration (HbO2). The delayed response phase represents an excess of incoming blood flow, which appears as an increase in HbO2/total Hb (tHb) and a decrease in HbR following the early response. In the surrounding area, cortical oxygenation change showed a monophasic response consisting of an increase in HbO2/tHb and a decrease in HbR. Combining TMS mapping with NIRS imaging enabled us to specify the cortex with the strongest functional activity.

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Authors and Affiliations

  1. Department of Neurosurgery, School of Medicine, Keio University, Tokyo, Japan

    Takenori Akiyama M.D., Takayuki Ohira & Takeshi Kawase

  2. Institute of Brain and Blood Vessels, Mihara Memorial Hospital, 366 Ootamachi, Isesaki city, Gunma, Japan

    Takenori Akiyama M.D.

  3. KATOBRAIN Corporation, 104-15-13 Shirokanedai 3, Minato-ku, Tokyo, Japan

    Toshinori Kato

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  1. Takenori Akiyama M.D.
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  2. Takayuki Ohira
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  3. Takeshi Kawase
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  4. Toshinori Kato
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Correspondence to Takenori Akiyama M.D..

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Akiyama, T., Ohira, T., Kawase, T. et al. TMS Orientation for NIRS-Functional Motor Mapping. Brain Topogr 19, 1–9 (2006). https://doi.org/10.1007/s10548-006-0007-9

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  • DOI: https://doi.org/10.1007/s10548-006-0007-9

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