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A new palladium-based antiproliferative agent: synthesis, characterization, computational calculations, cytotoxicity, and DNA binding properties

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Abstract

A new palladium(II) complex entitled [Pd(phendione)(8Q)]NO3, (PdPQ), where phendione is N,N-donor heterocyclic 1,10-phenanthroline-5,6-dion and 8Q is 8-hydroxyquinolinate, has been synthesized and then characterized by molar conductivity, CHN analysis and spectral data (UV–Vis, FT-IR, NMR). DFT/ TDDFT procedures were also performed to determine the electronic structure and the nature of the electronic transitions of PdPQ. Moreover, the affinity and binding properties of DNA to the desired complex have been studied in details using electronic absorption, fluorescence, circular dichroism spectroscopies, and viscosity measurement in combination with molecular docking technique. The obtained results exhibit relatively high DNA binding values with a static quenching mechanism, which suggest that an intercalative mode plays a peridominate role in interaction process concluded by experimental/theoretical measurements. As a result of drug exposure, in vitro cytotoxicity assay demonstrated the antiproliferative activity of the PdPQ against leukemia cancer cell line, K562.

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References

  • Adamo C, Barone V (1998) Exchange functionals with improved long-range behavior and adiabatic connection methods without adjustable parameters: The m PW and m PW1PW models. J Chem Phys 108:664–675

    Article  CAS  Google Scholar 

  • Adrian RA, Broker GA, Tiekink ERT, Walmsley JA (2008) Palladium (II) complexes of 1, 10-phenanthroline: Synthesis and X-ray crystal structure determination. Inorg Chim Acta 361:1261–1266

    Article  CAS  Google Scholar 

  • Aminzadeh M, Eslami A, Kia R, Aleeshah R (2017a) Synthesis, crystal structure, DFT calculation and DNA binding studies of new water-soluble derivatives of dppz. J Mol Struct 1145:141–151

    Article  CAS  Google Scholar 

  • Aminzadeh M, Mansouri-Torshizi H, Modarresi-Alam AR (2017b) 2, 2′-bipyridine coplanar with coordination square of Pd (II) nonyldithiocarbamato antitumor complex interacting with DNA in two distinct steps. J Biomol Struct Dyn 35:2301–2313

    Article  CAS  PubMed  Google Scholar 

  • Aminzadeh M, Eslami A, Kia R, Aleeshah R (2018) Synthesis, crystal structure and DNA interaction of a new water-soluble derivative of pyrazino [2, 3-f][1, 10] phenanthroline; theoretical calculations, experimental and molecular docking studies. J Mol Struct 1165:267–275

    Article  CAS  Google Scholar 

  • Aminzadeh M, Saeidifar M, Mansouri-Torshizi H (2020), Synthesis, characterization, DNA binding, cytotoxicity, and molecular docking approaches of Pd (II) complex with N, O-donor ligands as a novel potent anticancer agent. J Mol Str 128212.

  • Angeles-Boza AM, Bradley PM, Fu PK-L, Wicke SE, Bacsa J, Dunbar KR, Turro C (2004) DNA binding and photocleavage in vitro by new dirhodium (II) dppz complexes: correlation to cytotoxicity and photocytotoxicity. Inorg Chem 43:8510–8519

    Article  CAS  PubMed  Google Scholar 

  • Atasever B, Ülküseven B, Bal-Demirci T, Erdem-Kuruca S, Solakoǧlu Z (2010) Cytotoxic activities of new iron(III) and nickel(II) chelates of some S-methyl-thiosemicarbazones on K562 and ECV304 cells. Invest New Drugs 28:421–432

    Article  CAS  PubMed  Google Scholar 

  • Barbee J, Kuznetsov AE (2012) Revealing substituent effects on the electronic structure and planarity of Ni-porphyrins. Comput Theor Chem 981:73–85

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Becke AD (1993) Density-functional thermochemistry. III. The role of exact exchange. J Chem Phys 98:5648–5652

    Article  CAS  Google Scholar 

  • Bolognesi P, Mattioli G, O’Keeffe P, Feyer V, Plekan O, Ovcharenko Y, Prince K, Coreno M, Amore Bonapasta A, Avaldi L (2009) Investigation of halogenated pyrimidines by X-ray photoemission spectroscopy and theoretical DFT methods. J Phys Chem A 113:13593–13600

    Article  CAS  PubMed  Google Scholar 

  • Bushnell EAC, Boyd RJ (2015) Assessment of several DFT functionals in calculation of the reduction potentials for Ni–, Pd–, and Pt–Bis-ethylene-1, 2-dithiolene and-diselenolene complexes. J Phys ChemA 119:911–918

    Article  CAS  Google Scholar 

  • Calligaris M, Zangrando E, Milani B, Marson A (2005) Stereochemical investigation of palladium (II) complexes with phenanthroline ligands: a molecular mechanics approach. Eur J Inorg Chem 2005:704–712

    Article  CAS  Google Scholar 

  • Cances E, Mennucci B, Tomasi J (1997) A new integral equation formalism for the polarizable continuum model: Theoretical background and applications to isotropic and anisotropic dielectrics. J Chem Phys 107:3032–3041

    Article  CAS  Google Scholar 

  • Carbonell E, Martinez-Camarena A, Galiana-Rosello C, Inclan M, Tejero R, Yunta M, Navarro P, Gomez-Contreras F, Sanz A, Campayo L (2019) Acid–base behaviour and binding to double stranded DNA/RNA of benzo [g] phthalazine-based ligands. New J Chem 43:700–708

    Article  CAS  Google Scholar 

  • Check CE, Faust TO, Bailey JM, Wright BJ, Gilbert TM, Sunderlin LS (2001) Addition of polarization and diffuse functions to the LANL2DZ basis set for p-block elements. J Phys Chem A 105(34):8111–8116

    Article  CAS  Google Scholar 

  • Deegan C, Coyle B, McCann M, Devereux M, Egan DA (2006) In vitro anti-tumour effect of 1, 10-phenanthroline-5, 6-dione (phendione),[Cu (phendione) 3](ClO 4) 2· 4H 2 O and [Ag (phendione) 2] ClO 4 using human epithelial cell lines. Chem Biol Interact 164:115–125

    Article  CAS  PubMed  Google Scholar 

  • Dennington R, Keith T, Millam J (2009) GaussView, version 5. Semichem Inc., Shawnee Mission, KS

    Google Scholar 

  • Dikmen G, Ünver H (2021) A new Pd (II)-Hydrazide-Triphenylphosphine complex: Synthesis, crystal structure, spectroscopic characterization and theoretical calculations. J Mol Str 1225:129139

    Article  CAS  Google Scholar 

  • Divsalar A, Saboury AA, Mansoori-Torshizi H, Ahmad F (2010) Design, synthesis, and biological evaluation of a new palladium (II) complex: β-lactoglobulin and K562 as targets. J Phys Chem B 114:3639–3647

    Article  CAS  PubMed  Google Scholar 

  • Dreuw A, Dunietz BD, Head-Gordon M (2002) Characterization of the relevant excited states in the photodissociation of CO-ligated hemoglobin and myoglobin. J Am Chem Soc 124:12070–12071

    Article  CAS  PubMed  Google Scholar 

  • Duan R-R, Ou Z-B, Wang W, Chen S, Zhou X-H (2015) Synthesis, crystal structures, photoluminescence properties and DNA binding of triazine–nickel (II) complexes for DNA detection. Spectrochim Acta Part A Mol Biomol Spectrosc 151:64–71

    Article  CAS  Google Scholar 

  • Eslami Moghadam M, Saidifar M, Divsalar A, Mansouri-Torshizi H, Saboury AA, Farhangian H, Ghadamgahi M (2016) Rich spectroscopic and molecular dynamic studies on the interaction of cytotoxic Pt (II) and Pd (II) complexes of glycine derivatives with calf thymus DNA. J Biomol Str Dynam 34:206–222

    Article  CAS  Google Scholar 

  • Fatahian-Nezhad M, Alizadeh R, Mohammadi SS, Tohidlou M, Naderi-Manesh H, Amani V (2021) Synthesis, characterization, structural studies, DNA interaction, and cytotoxic studies of palladium (II) mixed-ligand complexes containing 2, 2′-bipyridine, 5, 6-dimethyl-1, 10-phenanthroline and tetrazole-5-thiol ligands. Inorg Chim Acta 514:119953

    Article  CAS  Google Scholar 

  • Ferreira LG, dos Santos RN, Oliva G, Andricopulo AD (2015) Molecular docking and structure-based drug design strategies. Molecules 20:13384–13421

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Frisch MJ, Pople JA, Stephen Binkley J (1984) Self-consistent molecular orbital methods 25 Supplementary functions for Gaussian basis sets. J Chem Phys 80(7):3265–3269

    Article  CAS  Google Scholar 

  • Fuentes L, Quiroga AG, Organero JA, Matesanz AI (2020) Exploring DNA binding ability of two novel α-N-heterocyclic thiosemicarbazone palladium (II) complexes. J Inorgan Biochem 203:110875

    Article  CAS  Google Scholar 

  • Gaussian RA, Frisch MJ, Trucks GW, Schlegel HB, Scuseria GE, Robb MA, Cheeseman JR, Scalmani G, Barone V, Mennucci B, Petersson GA et al (2009) Gaussian, Inc., Wallingford CT

  • Ghosh S, Barve AC, Kumbhar AA, Kumbhar AS, Puranik VG, Datar PA, Sonawane UB, Joshi RR (2006) Synthesis, characterization, X-ray structure and DNA photocleavage by cis-dichloro bis (diimine) Co (III) complexes. J Inorg Biochem 100:331–343

    Article  CAS  PubMed  Google Scholar 

  • Gill MR, Thomas JA (2012) Ruthenium (II) polypyridyl complexes and DNA—from structural probes to cellular imaging and therapeutics. Chem Soc Rev 41:3179–3192

    Article  CAS  PubMed  Google Scholar 

  • Hildebrandt J, Trautwein R, Kritsch D, Häfner N, Görls H, Dürst M, Runnebaum IB, Weigand W (2019) Synthesis, characterization and biological investigation of platinum (II) complexes with asparagusic acid derivatives as ligands. Dalton Trans 48:936–944

    Article  CAS  PubMed  Google Scholar 

  • Howe-Grant M, Wu KC, Bauer WR, Lippard SJ (1976) Binding of platinum and palladium metallointercalation reagents and antitumor drugs to closed and open DNAs. Biochemistry 15:4339–4346

    Article  CAS  PubMed  Google Scholar 

  • Islami-Moghaddam M, Mansouri-Torshizi H, Divsalar A, Saboury A (2009) Synthesis, characterization, cytotoxic and DNA binding studies of diimine platinum (II) and palladium (II) complexes of short hydrocarbon chain ethyldithiocarbamate ligand. J Iran Chem Soc 6:552–569

    Article  CAS  Google Scholar 

  • Jahanian-Najafabadi A, Mirian M, Rohani F, Karami K, Hosseini Kharat M, Sadeghi-Aliabadi H (2019) Novel palladium complex: cytotoxicity against cisplatin-resistant K562 cells. Iran J Pharmac Res 18(3):1323–1331

    CAS  Google Scholar 

  • Kenny RG, Marmion CJ (2019) Toward multi-targeted platinum and ruthenium drugs—a new paradigm in cancer drug treatment regimens. Chem Rev 119:1058–1137

    Article  CAS  PubMed  Google Scholar 

  • Klamt A, Moya C, Palomar J (2015) A comprehensive comparison of the IEFPCM and SS (V) PE continuum solvation methods with the COSMO approach. J Chem Theory Comput 11:4220–4225

    Article  CAS  PubMed  Google Scholar 

  • Kljun J, León IE, Peršič Š, Cadavid-Vargas JF, Etcheverry SB, He W, Bai Y, Turel I (2018) Synthesis and biological characterization of organoruthenium complexes with 8-hydroxyquinolines. J Inorg Biochem 186:187–196

    Article  CAS  PubMed  Google Scholar 

  • Komjáti B, Urai Á, Hosztafi S, Kökösi J, Kováts B, Nagy J, Horváth P (2016) Systematic study on the TD-DFT calculated electronic circular dichroism spectra of chiral aromatic nitro compounds: A comparison of B3LYP and CAM-B3LYP. Spectrochim Acta Part A Mol Biomol Spectrosc 155:95–102

    Article  CAS  Google Scholar 

  • Kondori T, Akbarzadeh-T N, Ghaznavi H, Karimi Z, Shahraki J, Sheervalilou RO, Shahraki O (2020) A binuclear iron(III) complex of 5,5′-dimethyl-2,2′-bipyridine as cytotoxic agent. Biometals 33:365–378

    Article  CAS  PubMed  Google Scholar 

  • Lazou M, Tarushi A, Gritzapis P, Psomas G (2020) Transition metal complexes with a novel guanine-based (E)-2-(2-(pyridin-2-ylmethylene) hydrazinyl) quinazolin-4 (3H)-one: Synthesis, characterization, interaction with DNA and albumins and antioxidant activity. J Inorgan Biochem 206:111019

    Article  CAS  Google Scholar 

  • Lenaerts P et al (2005) Thin Films of highly luminescent lanthanide complexes covalently linked to an organic− inorganic hybrid material via 2-substituted imidazo [4, 5-f]-1, 10-phenanthroline groups. Chem Mater 20:5194–5201

    Article  CAS  Google Scholar 

  • Lenaerts P, Storms A, Mullens J, D’Haen J, Görller-Walrand C, Binnemans K, Driesen K (2005) Thin Films of highly luminescent lanthanide complexes covalently linked to an organic− inorganic hybrid material via 2-substituted imidazo [4, 5-f]-1, 10-phenanthroline groups. Chem Mater 17:5194–5201

    Article  CAS  Google Scholar 

  • Liu X, Yang D, Ju H, Teng F, Hou Y, Lou Z (2011) Experimental and PCM/TD-DFT investigation on the absorption and emission spectra of a light emitting material in various solvents. Chem Phys Lett 503(1–3):75–79

    Article  CAS  Google Scholar 

  • Ma L, Ge K, Zhang R, Fu W, Li S, Wang S, Zhou G, Qin X, Zhang J (2014) Synthesis, characterization, cytotoxicity of mixed ligand complexes of palladium (II) with dipyrido [3, 2-d: 2′, 3′-f] quinoxaline/dipyrido [3, 2-a: 2′, 3′-c](6, 7, 8, 9-tetrahydro) phenazine and 4-toluensulfonyl-L-amino acid dianion. Eur J Med Chem 87:624–630

    Article  CAS  PubMed  Google Scholar 

  • Makedonas C, Mitsopoulou CA, Lahoz FJ, Balana AI (2003) Synthesis, characterization, and crystal structure of the Pd (phen)(bdt) complex. A DFT and TDDFT study of its ground electronic and excited states compared to those of analogous complexes. Inorgan Chem 42:8853–8865

    Article  CAS  Google Scholar 

  • Manojkumar Y, Ambika S, Senthilkumar R, Arunachalam S (2017) Biophysical and biological studies of some polymer grafted metallo-intercalators. Colloids Surf, B 156:320–329

    Article  CAS  Google Scholar 

  • Mansouri-Torshizi H, Mahboube I, Divsalar A, Saboury A-A (2008) 2, 2′-Bipyridinebutyldithiocarbamatoplatinum (II) and palladium (II) complexes: synthesis, characterization, cytotoxicity, and rich DNA-binding studies. Bioorg Med Chem 16:9616–9625

    Article  CAS  PubMed  Google Scholar 

  • Mansouri-Torshizi H, Moghaddam M, Divsalar A, Saboury A (2009) Diimine platinum (II) and palladium (II) complexes of dithiocarbamate derivative as potential antitumor agents: synthesis, characterization, cytotoxicity, and detail DNA-binding studies. J Biomol Struct Dyn 26:575–586

    Article  CAS  PubMed  Google Scholar 

  • Mansouri-Torshizi H, Saeidifar M, Divsalar A, Saboury AA (2010a) Interaction studies between a 1, 10-phenanthroline adduct of palladium (II) dithiocarbamate anti-tumor complex and calf thymus DNA. A synthesis spectral and in-vitro study. Spectrochim Acta Part A 77:312–318

    Article  CAS  Google Scholar 

  • Mansouri-Torshizi H, Saeidifar M, Rezaei-Behbehani G, Divsalar A, Saboury A (2010b) DNA binding studies and cytotoxicity of ethylenediamine 8-hydroxyquinolinato palladium (II) chloride. J Chin Chem Soc 57:1299–1308

    Article  CAS  Google Scholar 

  • Mansouri-Torshizi H, Saeidifar M, Divsalar A, Saboury AA (2010c) Interaction studies between a 1,10-phenanthroline adduct of palladium(II) dithiocarbamate anti-tumor complex and calf thymus DNA. A synthesis spectral and in-vitro study. Spectrochim Acta Part A 77:312–318

    Article  CAS  Google Scholar 

  • Matesanz AI, Jimenez-Faraco E, Ruiz MC, Balsa LM, Navarro-Ranninger C, León IE, Quiroga AG (2018) Mononuclear Pd (II) and Pt (II) complexes with an α-N-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction versus proven models from biological media. Inorganic Chemistry Frontiers 5:73–83

    Article  CAS  Google Scholar 

  • McNaught AD, Wilkinson A (1997) Compendium of chemical terminology, Blackwell Science Oxford

  • Mohammadi F, Mansouri-Torshizi H (2020) Five novel palladium (II) complexes of 8-hydroxyquinoline and amino acids with hydrophobic side chains: synthesis, characterization, cytotoxicity DNA-and BSA-interaction studies. J Biomol Str Dynam 38:3059–3073

    Article  CAS  Google Scholar 

  • Morris GM, Huey R, Lindstrom W, Sanner MF, Belew RK, Goodsell DS, Olson AJ (2009) AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility. J Comput Chem 30:2785–2791

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Musthafa M, Konakanchi R, Ganguly R, Balachandran C, Aoki S, Sreekanth A (2020) Synthesis, characterization, theoretical, molecular docking and in vitro biological activity studies of Ru (II)(η6-p-cymene) complexes with novel aniline substituted aroyl selenoureas. J Biomol Str Dynam 1–16.

  • Nakamoto K (2008) Infrared and raman spectra of inorganic and coordination compounds, theory and applications in inorganic chemistry, Wiley

  • Noodeh MF, Divsalar A, Seyedarabi A, Saboury AA (2018) Antiproliferative and interaction studies of a synthesized palladium (II) complex with human hemoglobin. J Mol Liq 249:265–271

    Article  CAS  Google Scholar 

  • Nwokeoji AO, Kilby PM, Portwood DE, Dickman MJ (2017) Accurate quantification of nucleic acids using hypochromicity measurements in conjunction with UV spectrophotometry. Anal Chem 89:13567–13574

    Article  CAS  PubMed  Google Scholar 

  • Özerkan D, Ertik O, Kaya B, Kuruca SE, Yanardag R, Ülküseven B (2019) Novel palladium (II) complexes with tetradentate thiosemicarbazones synthesis, characterization, in vitro cytotoxicity and xanthine oxidase inhibition. Invest New Drugs 37:1187–1197

    Article  PubMed  CAS  Google Scholar 

  • Peng X-H, Wang Y, Huang D, Wang Y, Shin HJ, Chen Z, Spewak MB, Mao H, Wang X, Wang Y (2011) Targeted delivery of cisplatin to lung cancer using ScFvEGFR-heparin-cisplatin nanoparticles. ACS Nano 5:9480–9493

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Perdew JP, Burke K, Wang Y (1996) Generalized gradient approximation for the exchange-correlation hole of a many-electron system. Phys Rev B 54:16533–16539

    Article  CAS  Google Scholar 

  • Ramachandran E, Senthil Raja D, Rath NP, Natarajan K (2013) Role of substitution at terminal nitrogen of 2-oxo-1, 2-dihydroquinoline-3-carbaldehyde thiosemicarbazones on the coordination behavior and structure and biological properties of their palladium (II) complexes. Inorgan Chem 52:1504–1514

    Article  CAS  Google Scholar 

  • Saeidifar M, Mansouri-Torshizi H, Palizdar Y, Eslami-Moghaddam M, Divsalar A, Saboury AA (2014) Synthesis, characterization, cytotoxicity and DNA binding studies of a novel anionic organopalladium (II) complex. Acta Chim Slov 61:126–136

    CAS  PubMed  Google Scholar 

  • Saeidifar M, Mansouri-Torshizi H, Saboury AA (2015) Biophysical study on the interaction between two palladium (II) complexes and human serum albumin by Multispectroscopic methods. J Lumin 167:391–398

    Article  CAS  Google Scholar 

  • Sathyaraj G, Weyhermüller T, Nair BU (2010) Synthesis, characterization and DNA binding studies of new ruthenium (II) bisterpyridine complexes. Eur J Med Chem 45:284–291

    Article  CAS  PubMed  Google Scholar 

  • Savić A, Marzo T, Scaletti F, Massai L, Bartoli G, Hoogenboom R, Messori L, Deun RV, Hecke KV (2019) New platinum(II) and palladium(II) complexes with substituted terpyridine ligands: synthesis and characterization, cytotoxicity and reactivity towards biomolecules. Biometals 32:33–47

    Article  PubMed  CAS  Google Scholar 

  • Scarpantonio L, Cotton S, Del Giorgio E, McCallum M, Hannon M, Pikramenou Z (2020) A luminescent europium hairpin for DNA photosensing in the visible, based on trimetallic bis-intercalators. J Inorgan Biochem 111119.

  • Scatchard G (1949) The attractions of proteins for small molecules and ions. Ann N Y Acad Sci 51:660–672

    Article  CAS  Google Scholar 

  • Singh SB, Kumbhar AS, Khan A (2016) Honeycomb-like ordered assembly of dna induced by flexible binuclear ruthenium (II)–polypyridyl complexes. Chemistry-A Eur J 22:15760–15771

    Article  CAS  Google Scholar 

  • Sorinezami Z, Mansouri-Torshizi H (2016) Photo-catalytic degradation of organic dyes: ultrasonic-assisted synthesis of PdO nanoparticles. J Mater Sci: Mater Electron 27:1558–1565

    CAS  Google Scholar 

  • Sorinezami Z, Mansouri-Torshizi H, Aminzadeh M, Ghahghaei A, Jamgohari N, Heidari Majd M (2019) Synthesis of new ultrasonic-assisted palladium oxide nanoparticles: an in vitro evaluation on cytotoxicity and DNA/BSA binding properties. J Biomol Str Dynam 37:4238–4250

    Article  CAS  Google Scholar 

  • Stratmann RE, Scuseria GE, Frisch MJ (1998) An efficient implementation of time-dependent density-functional theory for the calculation of excitation energies of large molecules. J Chem Phys 109:8218–8224

    Article  CAS  Google Scholar 

  • Talarico T, Phillips DR, Deacon GB, Rainone S, Webster LK (1999) Activity and DNA binding of new organoamidoplatinum (II) complexe. Invest New Drugs 17:1–15

    Article  CAS  PubMed  Google Scholar 

  • Terenzi A, Ducani C, Blanco V, Zerzankova L, Westendorf AF, Peinador C, Quintela JM, Bednarski PJ, Barone G, Hannon MJ (2012) DNA binding studies and cytotoxicity of a dinuclear PtII diazapyrenium-based metallo-supramolecular rectangular box. Chem-A Eur J 18:10983–10990

    Article  CAS  Google Scholar 

  • Wang Y, Okabe N (2005) X-ray structure characterization of palladium (II) ternary complexes of pyridinedicarboxylic and phthalic acid with phenanthroline and bipyridine. Chem Pharm Bull 53:366–373

    Article  CAS  Google Scholar 

  • Wei X, Yang Y, Ge J, Lin X, Liu D, Wang S, Zhang J, Zhou G, Li S (2020) Synthesis, characterization, DNA/BSA interactions and in vitro cytotoxicity study of palladium (II) complexes of hispolon derivatives. J Inorgan Biochem 202:110857

    Article  CAS  Google Scholar 

  • Xu H, Zheng K-C, Chen Y, Li Y-Z, Lin L-J, Li H, Zhang P-X, Ji L-N (2003) Effects of ligand planarity on the interaction of polypyridyl Ru (II) complexes with DNA. Dalton Trans. https://doi.org/10.1039/B300353A

    Article  Google Scholar 

  • Yadav S, Yousuf I, Usman M, Ahmad M, Arjmand F, Tabassum S (2015) Synthesis and spectroscopic characterization of diorganotin (IV) complexes of N′-(4-hydroxypent-3-en-2-ylidene) isonicotinohydrazide: chemotherapeutic potential validation by in vitro interaction studies with DNA/HSA DFT, molecular docking and cytotoxic activity. RSC Adv 5:50673–50690

    Article  CAS  Google Scholar 

  • Yanai T, Tew DP, Handy NC (2004) A new hybrid exchange–correlation functional using the Coulomb-attenuating method (CAM-B3LYP). Chem Phys Lett 393:51–57

    Article  CAS  Google Scholar 

  • Zhu M-C, Cui X-T, Zhao F-C, Ma X-Y, Han Z-B, Gao E-J (2015) Synthesis, characterization, and DNA interaction of novel Pt (ii) complexes and their cytotoxicity, apoptosis and molecular docking. RSC Adv 5:47798–47808

    Article  CAS  Google Scholar 

  • Zhu X, Peng Y, Qiu L (2017) Amino-functionalized nano-vesicles for enhanced anticancer efficacy and reduced myelotoxicity of carboplatin. Colloids Surf, B 157:56–64

    Article  CAS  Google Scholar 

  • Zianna A, Ristović MŠ, Psomas G, Hatzidimitriou A, Coutouli-Argyropoulou E, Lalia-Kantouri M (2016) Cadmium (II) complexes of 5-bromo-salicylaldehyde and α-diimines: synthesis, structure and interaction with calf-thymus DNA and albumins. Polyhedron 107:136–147

    Article  CAS  Google Scholar 

  • Živković M, Kljun J, Ilic-Tomic T, Pavic A, Veselinović A, Manojlović D, Nikodinovic-Runic J, Turel I (2018) A new class of platinum (II) complexes with the phosphine ligand pta which show potent anticancer activity. Inorgan Chem Front 5:39–53

    Article  Google Scholar 

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Acknowledgements

The authors are grateful for the support of Sistan and Baluchestan University and Materials and Energy Research Center.

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Authors and Affiliations

  1. Department of Chemistry, University of Sistan and Baluchestan, Zahedan, Iran

    Mohammad Aminzadeh, Hassan Mansouri-Torshizi & Khatereh Abdi

  2. Faculty of Chemistry, University of Mazandaran, Babolsar, Iran

    Mohammad Aminzadeh & Roghayeh Aleeshah

  3. Biomaterials Group, Nanotechnology and Advanced Materials, Materials and Energy Research Center, Karaj, Iran

    Maryam Saeidifar

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Material preparation, data collection and analysis were performed by MA, HMT and MS. The computational analysis were done by MA and RA. All authors participated in writing the first draft of the manuscript. All authors read and approved the final manuscript.

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Aminzadeh, M., Mansouri-Torshizi, H., Aleeshah, R. et al. A new palladium-based antiproliferative agent: synthesis, characterization, computational calculations, cytotoxicity, and DNA binding properties. Biometals 34, 1173–1189 (2021). https://doi.org/10.1007/s10534-021-00335-8

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