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After oxidation, zinc nanoparticles lose their ability to enhance responses to odorants

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Abstract

Electrical responses of olfactory sensory neurons to odorants were examined in the presence of zinc nanoparticles of various sizes and degrees of oxidation. The zinc nanoparticles were prepared by the underwater electrical discharge method and analyzed by atomic force microscopy and X-ray photoelectron spectroscopy. Small (1.2 ± 0.3 nm) zinc nanoparticles significantly enhanced electrical responses of olfactory neurons to odorants. After oxidation, however, these small zinc nanoparticles were no longer capable of enhancing olfactory responses. Larger zinc oxide nanoparticles (15 nm and 70 nm) also did not modulate responses to odorants. Neither zinc nor zinc oxide nanoparticles produced olfactory responses when added without odorants. The enhancement of odorant responses by small zinc nanoparticles was explained by the creation of olfactory receptor dimers initiated by small zinc nanoparticles. The results of this work will clarify the mechanisms for the initial events in olfaction, as well as to provide new ways to alleviate anosmia related to the loss of olfactory receptors.

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Acknowledgments

The work was funded by NIST Grant: 70 NANB14H324

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Authors and Affiliations

  1. Department of Anatomy, Physiology and Pharmacology, Auburn University College of Veterinary Medicine, Auburn, AL, USA

    Samantha Hagerty, Melissa Singletary, Oleg Pustovyy, Ludmila Globa, Edward E. Morrison, Iryna Sorokulova & Vitaly Vodyanoy

  2. Material Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, MD, USA

    Yasmine Daniels, William A. MacCrehan, Shin Muramoto, Gheorghe Stan & June W. Lau

  3. Auburn University, 109 Greene Hall, Auburn, AL, 36849, USA

    Vitaly Vodyanoy

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  1. Samantha Hagerty
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Hagerty, S., Daniels, Y., Singletary, M. et al. After oxidation, zinc nanoparticles lose their ability to enhance responses to odorants. Biometals 29, 1005–1018 (2016). https://doi.org/10.1007/s10534-016-9972-y

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