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The beneficial effects of intracoronary autologous bone marrow stem cell transfer as an adjunct to percutaneous coronary intervention in patients with acute myocardial infarction

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Abstract

The efficacy of post-percutaneous coronary intervention (PCI) intracoronary injection with bone marrow mesenchymal stem cells (BMSCs) in patients with acute myocardial infarction (AMI) remains controversial. Here, 58 patients with AMI undergoing PCI were randomly divided into two groups: BMSC and control groups. Autologous BSMCs were then generated in vitro from the BMSC patients. After transplantation, left ventricular ejection fraction (LVEF), left ventricular end-diastolic dimensions (LVDd), and infarct size (IS) were evaluated in both groups. LVEF, LVDd, and IS improved after BMSC transplantation but the changes were not significantly different from those in the controls. The number of adverse events and rehospitalization rates after 1 month were significantly higher in the control group than in the BMSC group. BMSC transplantation thus benefits patients by decreasing the number of adverse events and reducing the rehospitalization rate in the early stages following PCI.

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The authors have declared no conflict of interest.

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Authors and Affiliations

  1. Department of Cardiology, Shanghai First People’s Hospital, Affiliated Shanghai Jiaotong University, Shanghai, 200080, China

    Xiang Wang, Wei-chun Xi & Fang Wang

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  1. Xiang Wang
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  2. Wei-chun Xi
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  3. Fang Wang
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Correspondence to Fang Wang.

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Xiang Wang and Wei-chun Xi have contributed equally to this work.

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Wang, X., Xi, Wc. & Wang, F. The beneficial effects of intracoronary autologous bone marrow stem cell transfer as an adjunct to percutaneous coronary intervention in patients with acute myocardial infarction. Biotechnol Lett 36, 2163–2168 (2014). https://doi.org/10.1007/s10529-014-1589-z

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  • DOI: https://doi.org/10.1007/s10529-014-1589-z

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