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Paeoniflorin, a monoterpene glycoside, attenuates lipopolysaccharide-induced neuronal injury and brain microglial inflammatory response

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Abstract

Chronic activation of microglial cells endangers neuronal survival through the release of various proinflammatory and neurotoxic factors. Paeoniflorin (PF), a water-soluble monoterpene glycoside found in the root of Paeonia lactiflora Pall, has a wide range of pharmacological functions, such as anti-oxidant, anti-inflammatory, and anti-cancer effects. Neuroprotective potential of PF has also been demonstrated in animal models of neuropathologies. Here, we have examined the efficacy of PF in the repression of inflammation-induced neurotoxicity and microglial inflammatory response. In organotypic hippocampal slice cultures, PF significantly blocked lipopolysaccharide (LPS)-induced hippocampal cell death and productions of nitric oxide (NO) and interleukin (IL)-1β. PF also inhibited the LPS-stimulated productions of NO, tumor necrosis factor-α, and IL-1β from primary microglial cells. These results suggest that PF possesses neuroprotective activity by reducing the production of proinflammatory factors from activated microglial cells.

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Acknowledgments

This work was supported by the Basic Science Research Program (2010-0009164, the National Research Foundation, Korea).

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Authors and Affiliations

  1. Graduate School of East–West Medical Science, Kyung Hee University, 1 Seochun, Yongin-si, 446-701, Republic of Korea

    Kyong-Nyon Nam, Joung-Woo Hong, Dong-Hyung Cho & Eunjoo H. Lee

  2. Department of East–West Medical Science, Kyung Hee University, 1 Seochun, Yongin-si, 446-701, Republic of Korea

    Che Gyem Yae

  3. Myunggok Eye Research Institute, Konyang University College of Medicine, Nonsan, 320-711, Republic of Korea

    Joon H. Lee

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  1. Kyong-Nyon Nam
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  2. Che Gyem Yae
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  3. Joung-Woo Hong
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  4. Dong-Hyung Cho
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  5. Joon H. Lee
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  6. Eunjoo H. Lee
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Correspondence to Eunjoo H. Lee.

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Nam, KN., Yae, C.G., Hong, JW. et al. Paeoniflorin, a monoterpene glycoside, attenuates lipopolysaccharide-induced neuronal injury and brain microglial inflammatory response. Biotechnol Lett 35, 1183–1189 (2013). https://doi.org/10.1007/s10529-013-1192-8

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  • DOI: https://doi.org/10.1007/s10529-013-1192-8

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