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Delivery of recombinant bone morphogenetic proteins for bone regeneration and repair. Part B: Delivery systems for BMPs in orthopaedic and craniofacial tissue engineering

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Abstract

Localized and release-controlled delivery systems for the sustained expression of the biologic potency of rhBMPs are essential. A substantial number of biomaterials have been investigated thus far. Most fail after implantation or administration mainly due to either being too soft, difficult to control and/or stabilize mechanically. In the second part of this review, we review a representative selection of rhBMP-2 and rhBMP-7 carrier materials and delivery systems ranging from simple nano/microparticles to complex 3-D scaffolds in sites of orthopaedic and craniofacial bone regeneration and repair.

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Acknowledgments

The authors wish to thank grants from the Shriners of North America, Fonds de la Recherche en Santé du Québec, the National Science and Engineering Research Council, the Canadian Institutes of Health Research (CIHR)—Regenerative Medicine/Nanomedicine and the Center for Biorecognition and Biosensors (CBB), McGill University, Montréal, Québec, Canada. Dr. Haidar acknowledges scholarships from the Center for Bone and Periodontal Diseases Research and the Shriners Hospital, Montréal, Québec, Canada.

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  1. Faculty of Dentistry, McGill University, 740 Rue Dr. Penfield Suite # 4300, Montréal, QC, H3A 1A4, Canada

    Ziyad S. Haidar & Maryam Tabrizian

  2. Department of Biomedical Engineering, Faculty of Medicine, McGill University, Montréal, QC, Canada

    Ziyad S. Haidar & Maryam Tabrizian

  3. Center for Biorecognition and Biosensors, McGill University, 3775 University Street, Montréal, QC, H3A 2B4, Canada

    Ziyad S. Haidar, Reggie C. Hamdy & Maryam Tabrizian

  4. Shriners Hospital for Children and Division of Orthopaedics, Montreal Children’s Hospital, McGill University, 1529 Cedar Avenue, Montréal, QC, H3A 1A6, Canada

    Ziyad S. Haidar & Reggie C. Hamdy

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  1. Ziyad S. Haidar
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  2. Reggie C. Hamdy
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Correspondence to Maryam Tabrizian.

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Haidar, Z.S., Hamdy, R.C. & Tabrizian, M. Delivery of recombinant bone morphogenetic proteins for bone regeneration and repair. Part B: Delivery systems for BMPs in orthopaedic and craniofacial tissue engineering. Biotechnol Lett 31, 1825–1835 (2009). https://doi.org/10.1007/s10529-009-0100-8

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