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Biotechnological applications and potential of fungal feruloyl esterases based on prevalence, classification and biochemical diversity

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Abstract

Feruloyl esterases are part of the enzymatic spectrum employed by fungi and other microorganisms to degrade plant polysaccharides. They release ferulic acid and other aromatic acids from these polymeric structures and have received an increasing interest in industrial applications such as in the food, pulp and paper and bio-fuel industries. This review provides an overview of the current knowledge on fungal feruloyl esterases focussing in particular on the differences in substrate specificity, regulation of their production, prevalence of these enzymes in fungal genomes and industrial applications.

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References

  • Bach Tuyet Lam T, Iiyama K, Stone BA (1992) Cinnamic acid bridges between cell wall polymers in wheat and phalaris internodes. Phytochemistry 31:1179–1183

    Article  Google Scholar 

  • Bajpai P (1999) Application of enzymes in the pulp and paper industry. Biotechnol Prog 15:147–157

    Article  PubMed  CAS  Google Scholar 

  • Benoit I, Navarro D, Marnet N et al (2006) Feruloyl esterases as a tool for the release of phenolic compounds from agro-industrial by-products. Carbohydr Res 341:1820–1827

    Article  PubMed  CAS  Google Scholar 

  • Blum DL, Kataeva IA, Li XL et al (2000) Feruloyl esterase activity of the clostridium thermocellum cellulosome can be attributed to previously unknown domains of xyny and xynz. J Bacteriol 182:1346–1351

    Article  PubMed  CAS  Google Scholar 

  • Bonnin E, Grange H, Lesage-Meessen L et al (2000) Enzymic release of cellobiose from sugar beet pulp, and its use to favour vanillin production in pycnoporus cinnabarinus from vanillic acid. Carbohydr Polym 41:143–151

    Article  CAS  Google Scholar 

  • Borneman WS, Ljungdahl LG, Hartley RD et al (1991) Isolation and partial characterization of p-coumaroyl esterase from the anaerobic fungus neocallimastix strain mc-2. Appl Environ Microbiol 57:2337–2344

    PubMed  CAS  Google Scholar 

  • Borneman WS, Ljungdahl LG, Hartley RD et al (1992) Purification and partial characterization of two feruloyl esterases from the anaerobic fungus Neocallimastix strain mc-2. Appl Environ Microbiol 58:3762–3766

    PubMed  CAS  Google Scholar 

  • Chen JH, Ho C-T (1997) Antioxidant activities of caffeic acid and its related hydroxycinnamic acid compounds. J Agric Food Chem 45:2374–2378

    Article  CAS  Google Scholar 

  • Crepin VF, Faulds CB, Connerton IF (2003a) A non-modular type b feruloyl esterase from neurospora crassa exhibits concentration-dependent substrate inhibition. Biochem J 370:417–427

    Article  PubMed  CAS  Google Scholar 

  • Crepin VF, Faulds CB, Connerton IF (2003b) Production and characterization of the talaromyces stipitatus feruloyl esterase faec in Pichia pastoris: identification of the nucleophilic serine. Protein Expr Purif 29:176–184

    PubMed  CAS  Google Scholar 

  • Crepin VF, Faulds CB, Connerton IF (2004a) Functional classification of the microbial feruloyl esterases. Appl Microbiol Biotechnol 63:647–652

    Article  PubMed  CAS  Google Scholar 

  • Crepin VF, Faulds CB, Connerton IF (2004b) Identification of a type-d feruloyl esterase from Neurospora crassa. Appl Microbiol Biotechnol 63:567–570

    Article  PubMed  CAS  Google Scholar 

  • de Groot MJL, van de Vondervoort PJI, de Vries RP et al (2003) Isolation and characterization of two specific regulatory Aspergillus niger mutants shows antagonistic regulation of arabinan and xylan metabolism. Microbiology 149:1183–1191

    Article  PubMed  CAS  Google Scholar 

  • de Vries RP, Michelsen B, Poulsen CH et al (1997) The faea genes from Aspergillus niger and Aspergillus tubingensis encode ferulic acid esterases involved in the degradation of complex cell wall polysaccharides. Appl Environ Microbiol 63:4638–4644

    PubMed  Google Scholar 

  • de Vries RP, Visser J (1999) Regulation of the feruloyl esterase (faea) gene from Aspergillus niger. Appl Environ Microbiol 65:5500–5503

    PubMed  Google Scholar 

  • de Vries RP, Kester HCM, vanKuyk PA et al (2002) The Aspergillus niger faeb gene encodes a second feruloyl esterase involved in pectin and xylan degradation, and is specifically induced on aromatic compounds. Biochem J 363:377–386

    Article  PubMed  Google Scholar 

  • Desper R, Gascuel O (2002) Fast and accurate phylogeny reconstruction algorithms based on the minimum-evolution principle. J Comput Biol 9:687–705

    Article  PubMed  CAS  Google Scholar 

  • Donaghy J, McKay AM (1997) Purification and characterisation of a feruloyl esterase from the fungus Penicillium expansum. J Appl Microbiol 83:718–726

    Article  PubMed  CAS  Google Scholar 

  • Donaghy JA, McKay AM (1995) Production of feruloyl/rho-coumaroyl esterase activity by Penicillium expansum, Penicillium brevicompactum and Aspergillus niger. J Appl Bacteriol 79:657–662

    PubMed  CAS  Google Scholar 

  • Edgar RC (2004a) Muscle: a multiple sequence alignment method with reduced time and space complexity. BMC Bioinformatics 5:113

    Article  PubMed  CAS  Google Scholar 

  • Edgar RC (2004b) Muscle: multiple sequence alignment with high accuracy and high throughput. Nucleic Acids Res 32:1792–1797

    Article  PubMed  CAS  Google Scholar 

  • Faulds CB, Williamson G (1993) Ferulic acid esterase from Aspergillus niger: purification and partial characterization of two forms from a commercial source of pectinase. Biotechnol Appl Biochem 17:349–359

    PubMed  CAS  Google Scholar 

  • Faulds CB, Williamson G (1994) Purification and characterization of a ferulic acid esterase (fae-iii) from Aspergillus niger: specificity for the phenolic moiety and binding to microcrystalline cellulose. Microbiology 140:779–787

    Article  CAS  Google Scholar 

  • Faulds CB, de Vries RP, Kroon PA et al (1997) Influence of ferulic acid on the production of feruloyl esterases by Aspergillus niger. FEMS Microbiol Lett 157:239–244

    Article  PubMed  CAS  Google Scholar 

  • Felsenstein J (1989) Phylip—phylogeny inference package (version 3.2). Cladistics 5:164–166

    Google Scholar 

  • Fillingham IJ, Kroon PA, Williamson G et al (1999) A modular cinnamoyl ester hydrolase from the anaerobic fungus piromyces equi acts synergistically with xylanase and is part of a multiprotein cellulose-binding cellulase-hemicellulase complex. Biochem J 343:215–224

    Article  PubMed  CAS  Google Scholar 

  • Galtier N, Gouy M, Gautier C (1996) Seaview and phylo_win: two graphic tools for sequence alignment and molecular phylogeny. Comput Appl Biosci 12:543–548

    PubMed  CAS  Google Scholar 

  • Garcia-Conesa MT, Crepin VF, Goldson AJ et al (2004) The feruloyl esterase system of Talaromyces stipitatus: production of three discrete feruloyl esterases, including a novel enzyme, tsfaec, with a broad substrate specificity. J Biotechnol 108:227–241

    Article  PubMed  CAS  Google Scholar 

  • Grabber JH, Ralph J, Hatfield RD (1998) Ferulate cross-links limit the enzymatic degradation of synthetically lignified primary walls of maize. J Agric Food Chem 46:2609–2614

    Article  CAS  Google Scholar 

  • Grabber JH, Ralph J, Hatfield RD (2000) Cross-linking of maize walls by ferulate dimerization and incorporation into lignin. J Agric Food Chem 48:6106–6113

    Article  PubMed  CAS  Google Scholar 

  • Guindon S, Gascuel O (2003) A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood. Syst Biol 52:696–704

    Article  PubMed  Google Scholar 

  • Harhangi HR, Akhmanova A, Steenbakkers PJ et al (2003) Genomic DNA analysis of genes encoding (hemi-)cellulolytic enzymes of the anaerobic fungus piromyces sp. E2. Gene 314:73–80

    Article  PubMed  CAS  Google Scholar 

  • Ishii T (1991) Isolation and characterization of a diferuloyl arabinoxylan hexasaccharide from bamboo shoot cell-walls. Carbohydr Res 219:15–22

    Article  PubMed  CAS  Google Scholar 

  • Kantelinen A, Ratto M, Sundquist J et al (1988) Hemicelluloses and their potential role in bleaching. In International pulp bleaching conference, pp 1–9

  • Kikuzaki H, Hisamoto M, Hirose K et al (2002) Antioxidant properties of ferulic acid and its related compounds. J Agric Food Chem 50:2161–2168

    Article  PubMed  CAS  Google Scholar 

  • Klinke HB, Ahring BK, Schmidt AS et al (2002) Characterization of degradation products from alkaline wet oxidation of wheat straw. Bioresour Technol 82:15–26

    Article  PubMed  CAS  Google Scholar 

  • Koseki T, Furuse S, Iwano K et al (1998) Purification and characterization of a feruloylesterase from Aspergillus awamori. Biosci Biotechnol Biochem 62:2032–2034

    Article  PubMed  CAS  Google Scholar 

  • Koseki T, Takahashi K, Fushinobu S et al (2005) Mutational analysis of a feruloyl esterase from Aspergillus awamori involved in substrate discrimination and pH dependence. Biochim Biophys Acta 1722:200–208

    PubMed  CAS  Google Scholar 

  • Kroon PA, Faulds CB, Williamson G (1996) Purification and characterisation of a novel esterase induced by growth of Aspergillus niger on sugar-beet pulp. Biotechnol Appl Biochem 23:255–262

    PubMed  CAS  Google Scholar 

  • Kroon PA, Faulds CB, Brezillon C et al (1997) Methyl phenylalkanoates as substrates to probe the active sites of esterases. Eur J Biochem 248:245–251

    Article  PubMed  CAS  Google Scholar 

  • Kroon PA, Wiliamson G (1999) Hydroxycinnamates in plants and food: Current and future perspectives. J Sci Food Agric 79:355–361

    Article  CAS  Google Scholar 

  • Kroon PA, Williamson G, Fish NM et al (2000) A modular esterase from Penicillium funiculosum which releases ferulic acid from plant cell walls and binds crystalline cellulose contains a carbohydrate binding module. Eur J Biochem 267:6740–6752

    Article  PubMed  CAS  Google Scholar 

  • Lesage-Meessen L, Lomascolo A, Bonnin E et al (2002) A biotechnological process involving filamentous fungi to produce natural crystalline vanillin from maize bran. Appl Biochem Biotechnol 102–103:141–153

    Article  PubMed  Google Scholar 

  • MacAdam JW, Grabber JH (2002) Relationship of growth cessation with the formation of diferulate cross-links and p-coumaroylated lignins in tall fescue leaf blades. Planta 215:785–793

    Article  PubMed  CAS  Google Scholar 

  • Maillard MN, Berset C (1995) Evolution of antioxidant activity during kilning: Role of insoluble bound phenolic acids of barley and malt. J Agric Food Chem 43:1789–1793

    Article  CAS  Google Scholar 

  • Mayer AM, Staples RC (2002) Laccase: new functions for an old enzyme. Phytochemistry 60:551–565

    Article  PubMed  CAS  Google Scholar 

  • McCrae SI, Leith KM, Gordon AH et al (1994) Xylan degrading enzyme system produced by the fungus Aspergillus awamori: isolation and characterization of a feruloyl esterase and a p-coumaroyl esterase. Enzyme Microbiol Technol 16:826–834

    Article  CAS  Google Scholar 

  • Milstein O, Vered Y, Shragina L et al (1983) Metabolism of lignin related aromatic compounds by Aspergillus japonicus. Arch Microbiol 135:147–154

    Article  CAS  Google Scholar 

  • Murakami A, Nakamura Y, Koshimizu K et al (2002) Fa15, a hydrophobic derivative of ferulic acid, suppresses inflammatory responses and skin tumor promotion: comparison with ferulic acid. Cancer Lett 180:121–129

    Article  PubMed  CAS  Google Scholar 

  • Pel HJ, de Winde JH, Archer DB et al (2007) Genome sequence of Aspergillus niger strain cbs 513.88: a versatile cell factory. Nat Biotechnol 25:221–231

    Article  PubMed  Google Scholar 

  • Peleg H, Naim M, Zehavi U et al (1992) Pathways of 4-vinylguaiacol formation from ferulic acid in model solutions of orange juice. J Agric Food Chem 40

  • Ralet M-C, Faulds CB, Williamson G et al (1994) Degradation of feruloylated oligosaccharides from sugar beet pulp and wheat bran by ferulic acid esterases from Aspergillus niger. Carbohydr Res 263:257–269

    Article  PubMed  CAS  Google Scholar 

  • Ralph J, Grabber JH, Hatfield RD (1995) Lignin-ferulate crosslinks in grasses: active incorporation of ferulate polysaccharide esters into ryegrass lignins. Carbohydr Res 275:167–178

    Google Scholar 

  • Record E, Asther M, Sigoillot C et al (2003) Overproduction of the Aspergillus niger feruloyl esterase for pulp bleaching application. Appl Microbiol Biotechnol 62:349–355

    Article  PubMed  CAS  Google Scholar 

  • Rumbold K, Biely P, Mastihubova M et al (2003) Purification and properties of a feruloyl esterase involved in lignocellulose degradation by aureobasidium pullulans. Appl Environ Microbiol 69:5622–5626

    Article  PubMed  CAS  Google Scholar 

  • Shin HD, Chen RR (2007) A type b feruloyl esterase from Aspergillus nidulans with broad pH applicability. Appl Microbiol Biotechnol 73:1323–1330

    Article  PubMed  CAS  Google Scholar 

  • Sigoillot C, Camarero S, Vidal T et al (2005) Comparison of different fungal enzymes for bleaching high-quality paper pulps. J Biotechnol 115:333–343

    Article  PubMed  CAS  Google Scholar 

  • Tabka MG, Herpoël-Gimberta I, Monod F et al (2006) Enzymatic saccharification of wheat straw for bioethanol production by a combined cellulase xylanase and feruloyl esterase treatment. Enzyme Microbiol Technol 39:897–902

    Article  CAS  Google Scholar 

  • Tapin S, Sigoillot J-C, Asther M et al (2006) Feruloyl esterase utilization for simultaneous processing of nonwood plants into phenolic compounds and pulp fibers. J Agric Food Chem 54:3697–3703

    Article  CAS  PubMed  Google Scholar 

  • Tenkanen M, Schuseil J, Puls J et al (1991) Production, purification and characterisation of an esterase liberating phenolic acids from lignocellulosics. J Biotechnol 18:69–84

    Article  CAS  Google Scholar 

  • Topakas E, Stamatis H, Biely P et al (2003) Purification and characterization of a feruloyl esterase from fusarium oxysporum catalyzing esterification of phenolic acids in ternary water–organic solvent mixtures. J Biotechnol 102:33–44

    Article  PubMed  CAS  Google Scholar 

  • Topakas E, Stamatis H, Biely P et al (2004) Purification and characterization of a type b feruloyl esterase (stfae-a) from the thermophilic fungus sporotrichum thermophile. Appl Microbiol Biotechnol 63:686–690

    Article  PubMed  CAS  Google Scholar 

  • Vailhe MA, Provan GJ, Scobbie L et al (2000) Effect of phenolic structures on the degradability of cell walls isolated from newly extended apical internode of tall fescue (Festuca arundinacea schreb.). J Agric Food Chem 48:618–623

    Article  PubMed  CAS  Google Scholar 

  • van Gorcom RFM, Boschloo JG, Kuijvenhoven A et al (1990) Isolation and molecular characterisation of the benzoate-para-hydroxylase gene (bpha) of Aspergillus niger: a member of a new gene family of the cytochrome p450 superfamily. Mol Gen Genet 233:192–197

    Google Scholar 

  • van Peij N, Gielkens MMC, de Vries RP et al (1998a) The transcriptional activator xlnr regulates both xylanolytic and endoglucanase gene expression in Aspergillus niger. Appl Environ Microbiol 64:3615–3619

    PubMed  Google Scholar 

  • van Peij NNME, Visser J, de Graaff LH (1998b) Isolation and analysis of xlnr, encoding a transcriptional activator coordinating xylanolytic expression in Aspergillus niger. Mol Microbiol 27:131–142

    Article  PubMed  Google Scholar 

  • Zheng L, Zheng P, Sun Z et al (2007) Production of vanillin from waste residue of rice bran oil by Aspergillus niger and Pycnoporus cinnabarinus. Bioresour Technol 98:1115–1119

    Article  PubMed  CAS  Google Scholar 

  • Zmasek CM, Eddy SR (2001) Atv: display and manipulation of annotated phylogenetic trees. Bioinformatics 17:383–384

    Article  PubMed  CAS  Google Scholar 

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Acknowledgements

R.P. de Vries was supported by The Netherlands Technology Foundation (STW) VIDI project UGC.7063.

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Correspondence to Ronald P. de Vries.

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Benoit, I., Danchin, E.G.J., Bleichrodt, RJ. et al. Biotechnological applications and potential of fungal feruloyl esterases based on prevalence, classification and biochemical diversity. Biotechnol Lett 30, 387–396 (2008). https://doi.org/10.1007/s10529-007-9564-6

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  • DOI: https://doi.org/10.1007/s10529-007-9564-6

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