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Anti-diabetic activity of β-glucans and their enzymatically hydrolyzed oligosaccharides from Agaricus blazei

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Abstract

β-Glucans were prepared from Agaricus blazei Murill by repeated extraction with hot water. The average molecular weights of β-glucans were 30–50 kDa by gel filtration chromatography. Oligosaccharides (AO), derived from hydrolyzing β-glucans with an endo-β-(1→6)-glucanase from Bacillus megaterium, were mainly di- and tri-saccharides. Though β-glucans and AO both showed anti-hyperglycemic, anti-hypertriglyceridemic, anti-hypercholesterolemic, and anti-arteriosclerotic activity indicating overall anti-diabetic activity in diabetic rats, AO had about twice the activity of β-glucans with respect to anti-diabetic activity.

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Authors and Affiliations

  1. Department of Biomedical Laboratory Science and Biohealth Products Research Center, Inje University, Gimhae, 621-749, Republic of Korea

    Yea-Woon Kim, Ki-Hoon Kim, Hyun-Ju Choi & Dong-Seok Lee

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  1. Yea-Woon Kim
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  2. Ki-Hoon Kim
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  3. Hyun-Ju Choi
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  4. Dong-Seok Lee
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Correspondence to Dong-Seok Lee.

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Kim, YW., Kim, KH., Choi, HJ. et al. Anti-diabetic activity of β-glucans and their enzymatically hydrolyzed oligosaccharides from Agaricus blazei. Biotechnol Lett 27, 483–487 (2005). https://doi.org/10.1007/s10529-005-2225-8

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  • DOI: https://doi.org/10.1007/s10529-005-2225-8

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