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Polymorphic Variation of CYP1A1 and CYP1B1 Genes in a Haryana Population

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Abstract

Cytochrome P450 (CYP) 1A1 and CYP1B1 are important phase I xenobiotic metabolizing enzymes involved in the metabolism of numbers of toxins, endogenous hormones, and pharmaceutical drugs. Polymorphisms in these phase I genes can alter enzyme activity and are known to be associated with cancer susceptibility related to environmental toxins and hormone exposure. Their genotypes may also display ethnicity-dependent population frequencies. The present study was aimed to determine the frequencies of commonly known functional polymorphisms of CYP1A1 and CYP1B1 genes in a Haryana state population of North India. The allelic frequency of CYP1A1 polymorphism m1 (MspI) was 29.65% and m2 (Ile462Val) was 24.85%. The frequency of CYP1B1 polymorphism m1 (Val432Leu) was 45.85% and m2 (Asn453Ser) was 16.2%. We observed inter- and intra-ethnic variation in the frequency distribution of these polymorphisms. Analysis of polymorphisms in these genes might help in predicting the risk of cancer. Our results emphasize the need for more such studies in high-risk populations.

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Acknowledgments

This research was proposed and guided by Dr. Anita Yadav. We are thankful to the University Grant Commission, New Delhi, India, for funding and to all blood donors for their voluntary participation in the study.

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Authors and Affiliations

  1. Department of Biotechnology, Kurukshetra University, Kurukshetra, 136119, Haryana, India

    Shiv Kumar Giri, Anita Yadav, Anil Kumar, Kapil Dev, Sachin Gulati & Sanjeev Kumar Gautam

  2. Department of Biochemistry, Kurukshetra University, Kurukshetra, 136119, Haryana, India

    Ranjan Gupta

  3. Department of Microbiology, Kurukshetra University, Kurukshetra, 136119, Haryana, India

    Neeraj Aggarwal

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  1. Shiv Kumar Giri
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  2. Anita Yadav
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Correspondence to Anita Yadav.

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Giri, S.K., Yadav, A., Kumar, A. et al. Polymorphic Variation of CYP1A1 and CYP1B1 Genes in a Haryana Population. Biochem Genet 51, 853–864 (2013). https://doi.org/10.1007/s10528-013-9612-y

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  • DOI: https://doi.org/10.1007/s10528-013-9612-y

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