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Radiation-induced life span alteration of Drosophila lines with genotype differences

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Abstract

The research shows that unirradiated Drosophila lines with defects of DNA repair, antioxidant protection and apoptosis have higher speed of ageing, than wild type line. At the same time, depending on the line genotype, the irradiation results in change of life span. Mechanism of postponed effect of low dozes of ionizing radiation on the life span is elaborated. As cells with weakened protection will accumulate damages and will be exposed to ageing with the greater speed, than steady cells, their radio-induced elimination at early development stages will result in delay of age-dependent changes and will lower speed of ageing. In the subsequent irradiated generations the given somatic answer to stress (hormesis) may be replaced by negative genetic effects on the population level (shorter life span).

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References

  • Aravind L, Dixit VM, Koonin EV (2001) Apoptotic molecular machinery: vastly increased complexity in vertebrates revealed by genome comparisons. Science 291:1279–1284

    Article  PubMed  CAS  Google Scholar 

  • Ashburner M (1989) Drosophila: a laboratory handbook. Cold Spr Harb Lab Press, Newyork, p 1331

    Google Scholar 

  • Le Bourg E, Minois N, Bullens P, Baret P (2000) A mild stress due to hypergravity exposure at young age increases longevity in Drosophila melanogaster males. Biogerontology 1:145–155

    Article  PubMed  CAS  Google Scholar 

  • Rattan SI (2001) Hormesis in biogerontology. Crit rev toxicol 31:663–664

    Article  PubMed  CAS  Google Scholar 

  • Sacher GA (1963) Effects of X-rays on the survival of Drosophila imagoes. Physiol Zool 36:295–311

    Google Scholar 

  • Upton AC (2001) Radiation hormesis: data and interpretations. Crit rev toxicol 31:681–695

    Article  PubMed  CAS  Google Scholar 

  • Vorobtsova IE (1963) Comparative studying of radiosensitivity of various lines of Drosophila melanogaster. Proc of Academy of Science of USSR 153:943–946

    Google Scholar 

  • Zainullin VG, Moskalev AA, Shaposhnikov MV, Taskaev AI (1999) Current aspects of radiobiology of Drosophila melanogaster. Apoptosis and aging. Radiat biol Radioecol (RUSSIA) 39:49–57

    CAS  Google Scholar 

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Authors and Affiliations

  1. Institute of Biology, Komi Science Center of Russian Academy of Sciences, Kommunisticheskaja St. 28, Syktyvkar, 167982, Russia

    Alexey Moskalev

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  1. Alexey Moskalev
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Correspondence to Alexey Moskalev.

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Moskalev, A. Radiation-induced life span alteration of Drosophila lines with genotype differences. Biogerontology 8, 499–504 (2007). https://doi.org/10.1007/s10522-007-9090-x

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  • DOI: https://doi.org/10.1007/s10522-007-9090-x

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