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A revolution for aging research

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Abstract

In the year 1992, two publications on age-specific mortality rates revealed a cessation of demographic aging at later ages in very large cohorts of two dipteran species reared under a variety of conditions. Despite some initial concerns about possible artifacts, these findings have now been amply corroborated in the experimental literature. The eventual cessation of aging undermines the credibility of simple Gompertzian aging models based on a protracted acceleration in age-specific mortality during adulthood. The first attempt to explain the apparent cessation of aging was extreme lifelong heterogeneity among groups with respect to frailty. This lifelong heterogeneity theory assumes an underlying Gompertzian aging affecting every member of an adult cohort, with a merely apparent cessation of aging explained in terms of the increasing domination of a slowly aging group among the survivors to late ages. This theory has received several experimental refutations. The second attempt to explain the cessation of aging applied force of natural selection theory. This explanation of the cessation of aging has been corroborated in several Drosophila experiments. In particular, this theory requires that both age-specific survival and age-specific fecundity cease declining in late life, which has now been experimentally established. This theory also predicts that the timing of the cessation of aging should depend on the last age of reproduction in a population’s evolutionary history, a prediction that has been corroborated. While lifelong heterogeneity should reduce average age-specific mortality in late life whenever it is pronounced, the cessation of aging in late life can be explained by plateaus in the forces of natural selection whether lifelong heterogeneity is present or not. The discovery that aging ceases is one of the most significant discoveries in recent aging research, with potentially revolutionary scientific implications.

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References

  • Baudisch A (2005) Hamilton’s indicators of the force of selection. Proc Natl Acad Sci USA 102: 8263–8268

    Article  PubMed  CAS  Google Scholar 

  • Beard RE (1959) Note on some mathematical mortality models. In: Wolstenholme GEW, O’Conner M (eds) The Lifespan of Animals. Little Brown, Boston, pp. 302–311

    Google Scholar 

  • Carey JR, Liedo P, Orozco D, and Vaupel JW (1992) Slowing of mortality rates at older ages in large medfly cohorts. Science 258: 457–461

    Article  PubMed  CAS  Google Scholar 

  • Charlesworth B (1980) Evolution in Age-structured Populations. Cambridge University Press, London

    Google Scholar 

  • Charlesworth B (1994) Evolution in Age-structured Populations, 2nd ed. Cambridge University Press, London

    Google Scholar 

  • Charlesworth B (2001) Patterns of age-specific means and genetic variances of morality rates predicted by the mutation-accumulation theory of ageing. J Theor Biol 210: 47–65

    Article  PubMed  CAS  Google Scholar 

  • Comfort A (1964) Ageing: The biology of senescence, Fig. 18, p. 90. Routledge and Kegan Paul, London

    Google Scholar 

  • Curtsinger JW (1995) Density and age-specific mortality. Genetica 96: 179–182

    Article  PubMed  CAS  Google Scholar 

  • Curtsinger JW, Fukui HH, Townsend DR, and Vaupel JW (1992) Demography of genotypes: failure of the limited life span paradigm in Drosophila melanogaster. Science 258: 461–463

    Article  PubMed  CAS  Google Scholar 

  • Curtsinger JW, Gavrilova NS and Gavrilov LA (2005) Biodemography of aging and age-specific mortality in Drosophila melanogaster. In: Masoro EJ, Austad SN (eds) Handbook of the Biology of Aging, Sixth Edition. Elsevier Academic Press, San Diego, CA, USA, pp. 265–292

    Google Scholar 

  • Drapeau MD, Gass EK, Simison MD, Mueller LD, and Rose MR (2000) Testing the heterogeneity theory of late-life mortality plateaus by using cohorts of Drosophila melanogaster. Exp Gerontol 35: 71–84

    Article  PubMed  CAS  Google Scholar 

  • Economos AC (1979) A non-human Gompertzian paradigm for mortality kinetics of metazoan animals and failure kinetics of manufactured products. Age 2: 74–76

    Article  Google Scholar 

  • Finch CE (1990) Longevity, Senescence, and the Genome. University of Chicago Press, Chicago

    Google Scholar 

  • Fukui HH, Xiu L, and Curtsinger JW (1993) Slowing of age-specific mortality rates in Drosophila melanogaster. Exp Gerontol 28: 585–599

    Article  PubMed  CAS  Google Scholar 

  • Gavrilov LA, and Gavrilova NS (1991) The Biology of Lifespan: A Quantitative Approach. Harwood Academic Publishers, New York

    Google Scholar 

  • Gavrilov LA, and Gavrilova NS (2001) The reliability theory of aging and longevity. J Theor Biol 213: 527–545

    Article  PubMed  CAS  Google Scholar 

  • Graves JL Jr, and Mueller LD (1993) Population density effects on longevity. Genetica 91: 99–109

    Article  PubMed  Google Scholar 

  • Greenwood M, and Irwin JO (1939) Biostatistics of senility. Hum Biol 11: 1–23

    Google Scholar 

  • Hamilton WD (1966) The moulding of senescence by natural selection. J Theor Biol 12: 12–45

    Article  PubMed  CAS  Google Scholar 

  • Joshi A, Shiotsugu J, and Mueller LD (1996) Phenotypic enhancement of longevity by environmental urea in Drosophila melanogaster. Exp Gerontol 31: 533–544

    Article  PubMed  CAS  Google Scholar 

  • Khazaeli AA, Xiu L, and Curtsinger JW (1995) Effect of adult cohort density on age-specific mortality in Drosophila melanogaster. J Gerontol Ser A Biol Sci Med Sci 50: 262–269

    Google Scholar 

  • Khazaeli AA, Xiu L, and Curtsinger JW (1996) Effect of density on age-specific mortality in Drosophila: a density supplementation experiment. Genetica 98: 21–31

    Article  PubMed  CAS  Google Scholar 

  • Khazaeli AA, Pletcher SD, and Curtsinger JW (1998) The fractionation experiment: reducing heterogeneity to investigate age-specific mortality in Drosophila. Mech Ageing Dev 105: 301–317

    Article  PubMed  CAS  Google Scholar 

  • Kowald A, and Kirkwood TBL (1993) Explaining fruit fly longevity (Technical Comment). Science 260: 1664–1665

    Article  PubMed  CAS  Google Scholar 

  • Kuhn TS (1962) The Structure of Scientific Revolutions. University of Chicago Press, Chicago, IL

    Google Scholar 

  • Luckinbill LS, Arking R, Clare MJ, Cirocco WC, and Buck SA (1984) Selection for delayed senescence in Drosophila melanogaster. Evolution 38: 996–1003

    Article  Google Scholar 

  • Maynard Smith J, Barker DJP, Finch CE, Kardia SLR, Eaton SB, Kirkwood TBL, LeGrand E, Nesse RM, Williams GC, and Partridge L (1999) The evolution of non-infectious and degenerative disease. In: Stearns SC (ed) Evolution in Health and Disease. Oxford University Press, Oxford, pp. 267–272

    Google Scholar 

  • Mueller LD, and Rose MR (1996) Evolutionary theory predicts late-life mortality plateaus. Proc Natl Acad Sci USA 93: 15249–15253

    Article  PubMed  CAS  Google Scholar 

  • Mueller LD, Drapeau MD, Adams CS, Hammerle CW, Doyal KM, Jazayeri AJ, Ly T, Beguwala SA, Mamidi AR, and Rose MR (2003) Statistical tests of demographic heterogeneity theories. Exp Gerontol 38: 373–386

    Article  PubMed  Google Scholar 

  • Nusbaum TJ, Graves JL, Mueller LD, and Rose MR (1993) Fruit fly aging and mortality (Letter). Science 260: 1567

    Article  PubMed  CAS  Google Scholar 

  • Nusbaum TJ, Mueller LD, and Rose MR (1996) Evolutionary patterns among measures of aging. Exp Gerontol 31: 507–516

    Article  PubMed  CAS  Google Scholar 

  • Olshansky SJ (1998) On the biodemography of aging: a review essay. Popul Dev Rev 24: 381–393

    Article  Google Scholar 

  • Pletcher SD, and Curtsinger JW (1998) Mortality plateaus and the evolution of senescence: why are old-age mortality rates so low? Evolution 52: 454–464

    Article  Google Scholar 

  • Popper KR (1959) The Logic of Scientific Discovery. Basic Books, New York, NY

    Google Scholar 

  • Provine WB (1971) The Origins of Theoretical Population Genetics. University of Chicago Press, Chicago, IL

    Google Scholar 

  • Rauser CL, Mueller LD, and Rose MR (2003) Aging, fertility and immortality. Exp Gerontol 38: 27–33

    Article  PubMed  Google Scholar 

  • Rauser CL, Abdel-Aal Y, Sheih JA, Suen CW, Mueller LD, and Rose MR (2005) Lifelong heterogeneity in fecundity is insufficient to explain late-life fecundity plateaus in Drosophila melanogaster. Exp Gerontol 40: 660–670

    Article  PubMed  Google Scholar 

  • Rauser CL, Tierney JJ, Gunion SM, Covarrubias GM, Mueller LD and Rose MR (2006a) Evolution of late-life fecundity in Drosophila melanogaster. J Evol Biol 19: 289–301

    Article  CAS  Google Scholar 

  • Rauser CL, Rose MR and Mueller LD (2006b) The evolution of late life. Ageing Res Rev 5: 14–32

    Article  Google Scholar 

  • Roff DA (1992) The Evolution of Life Histories: Theory and Analysis. Chapman and Hall, New York

    Google Scholar 

  • Rose MR (1984) Laboratory evolution of postponed senescence in Drosophila melanogaster. Evolution 38: 1004–1010

    Article  Google Scholar 

  • Rose MR (1991) Evolutionary Biology of Aging. Oxford University Press, New York, NY

    Google Scholar 

  • Rose MR, and Finch CE (1994) Genetics and Evolution of Aging. Kluwer Academic Publishers, Dordrecht, the Netherlands

    Google Scholar 

  • Rose MR, Drapeau MD, Yazdi PG, Shah KH, Moise DB, Thakar RR, Rauser CL, and Mueller LD (2002) Evolution of late-life mortality in Drosophila melanogaster. Evolution 56: 1982–1991

    PubMed  Google Scholar 

  • Rose MR, Passananti HB, and Matos M, (eds) (2004) Methuselah Flies: A Case Study in the Evolution of Aging. World Scientific Press, Singapore

    Google Scholar 

  • Service PM (2000) Heterogeneity in individual morality risk and its importance for evolutionary studies of senescence. Am Nat 156: 1–13

    Article  PubMed  Google Scholar 

  • Service PM (2004) Demographic heterogeneity explains age-specific patterns of genetic variance in mortality rates. Exp Gerontol 39: 25–30

    Article  PubMed  Google Scholar 

  • Stearns SC (1992) The Evolution of Life Histories. Oxford University Press, Oxford

    Google Scholar 

  • Vaupel JW (1988) Inherited frailty and longevity. Demography 25: 277–287

    Article  PubMed  CAS  Google Scholar 

  • Vaupel JW, Carey JR, Christensen K, Johnson TE, Yashin AI, Holm NV, Iachine IA, Kannisto V, Khazaeli AA, Liedo P, Longo VD, Zeng Y, Manton KG, and Curtsinger JW (1998) Biodemographic trajectories of longevity. Science 280: 855–860

    Article  PubMed  CAS  Google Scholar 

  • Wachter KW (1999) Evolutionary demographic models for mortality plateaus. Proc Natl Acad Sci USA 96: 10544–10547

    Article  PubMed  CAS  Google Scholar 

  • Weitz J and Fraser H (2001) Explaining mortality rate plateaus. Proc Natl Acad Sci USA 98: 15,383–15,386

    Article  CAS  Google Scholar 

Download references

Acknowledgments

The authors are grateful to J.W. Curtsinger for reviewing the manuscript prior to submission. Our research on late life has been supported by an NIH grant to J. Tower and MRR, a Sigma Xi grant to CLR, and an NSF-DDIG award to MRR and CLR.

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Authors and Affiliations

  1. Department of Ecology and Evolutionary Biology, University of California, Irvine, CA, 92697-2525, USA

    Michael R. Rose, Casandra L. Rauser & Laurence D. Mueller

  2. Department of Physics and Astronomy, University of California, Irvine, CA, 92697, USA

    Gregory Benford

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  1. Michael R. Rose
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  2. Casandra L. Rauser
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  3. Laurence D. Mueller
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  4. Gregory Benford
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Correspondence to Michael R. Rose.

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Rose, M.R., Rauser, C.L., Mueller, L.D. et al. A revolution for aging research. Biogerontology 7, 269–277 (2006). https://doi.org/10.1007/s10522-006-9001-6

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