We analyzed the expression of the transcription factor Oct4 in the chromaffin cells during the postnatal development of the adrenal glands in rats. Single Oct4+-chromaffin cells with nuclear localization of the protein were found in the medulla, and their number increased in parallel with a decrease in the proliferative activity of cells. In postnatal development, 100% of chromaffin cells demonstrated high expression of tyrosine hydroxylase, which attested to their differentiation and functional activity. It was found that all Oct4+ cells were differentiated chromaffin cells. An increase in the pool of Oct4-expressing cells after the completion of organ growth suggests the formation of a potential source for the physiological and reparative regeneration of the adrenal medulla.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 173, No. 6, pp. 775-778, June, 2022
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Yaglova, N.V., Obernikhin, S.S., Nazimova, S.V. et al. Changes in the Expression of Transcription Factor Oct4 during Postnatal Development of Adrenal Medulla. Bull Exp Biol Med 173, 783–786 (2022). https://doi.org/10.1007/s10517-022-05631-y
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DOI: https://doi.org/10.1007/s10517-022-05631-y