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Strategy of Pharmacological Regulation of Intracellular Signal Transduction in Regeneration-Competent Cells

  • PHARMACOLOGY AND TOXICOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

The study focuses on the development of principally novel priority-oriented healthcare strategy — targeted therapy in regenerative medicine known as Strategy of Pharmacological Control over Intracellular Signal Transduction in Regeneration-Competent Cells. It implies selective action of promising drugs on specific key elements in the signaling cascade responsible for functional activity of various progenitor cells (including stem cells) and elements of tissue microenvironment. The results of pioneer studies are described that were aimed on revealing the peculiarities in signal transduction and the role of distinct signaling molecules (the potential targets) in the control of cell cycle and other functions of progenitor elements and regulatory cells of different types. The models of some pathological states were employed to demonstrate the possibility of effective implementation of the advanced pharmacotherapeutic concept. The developed theoretical and applied platform can be used to launch synthesis of principally novel preparations with regenerative activity.

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Authors and Affiliations

  1. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Tomsk, Russia

    G. N. Zyuz’kov, V. V. Zhdanov, E. V. Udut, L. A. Miroshnichenko, T. Yu. Polyakova, L. A. Stavrova & V. V. Udut

  2. National Research Tomsk State University, Tomsk, Russia

    E. V. Udut & V. V. Udut

Authors
  1. G. N. Zyuz’kov
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  2. V. V. Zhdanov
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  3. E. V. Udut
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  4. L. A. Miroshnichenko
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  5. T. Yu. Polyakova
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  6. L. A. Stavrova
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  7. V. V. Udut
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Corresponding author

Correspondence to G. N. Zyuz’kov.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 166, No. 10, pp. 435-445, October, 2018

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Zyuz’kov, G.N., Zhdanov, V.V., Udut, E.V. et al. Strategy of Pharmacological Regulation of Intracellular Signal Transduction in Regeneration-Competent Cells. Bull Exp Biol Med 166, 448–455 (2019). https://doi.org/10.1007/s10517-019-04370-x

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  • DOI: https://doi.org/10.1007/s10517-019-04370-x

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