We studied the effects of prenatal and postnatal exposure to low doses of DDT on secretion of basic catecholamines epinephrine and norepinephrine in pubertal and adult rats. It was found that the endocrine-disrupting chemical under study led to a progressive decrease in the content of epinephrine and especially norepinephrine in systemic circulation, which indicated their disturbed secretion by the adrenal medulla and sympathetic nervous system cells. In animals exposed to low doses of DDT in both pre- and postnatal periods, the decrease in catecholamine secretion after puberty was less pronounced than in animals exposed only during the postnatal period, which can indicate the development of compensatory processes.
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References
Hygienic Requirements for the Safety and Nutritional Value of Food. SanPin 2.3.2.1078-01, November 6, 2001.
Yaglova NV, Yaglov VV. Changes in thyroid status of rats after prolonged exposure to low dose dichlorodiphenyltrichloroethane. Bull. Exp. Biol. Med. 2013;156(6):760-762.
Gray LE Jr, Wilson VS, Stoker T, Lambright C, Furr J, Noriega N, Howdeshell K, Ankley GT, Guillette L. Adverse effects of environmental antiandrogens and androgens on reproductive development in mammals. Int. J. Androl. 2006;29(1):96-104.
Mnif W, Hassine AI, Bouaziz A, Bartegi A, Thomas O, Roig B. Effect of endocrine disruptor pesticides: a review. Int. J. Environ. Res. Public Health. 2011;8(6):2265-2303.
Polanczyk G, de Lima MS, Horta BL, Biederman J, Rohde LA. The worldwide prevalence of ADHD: a systematic review and metaregression analysis. Am. J. Psychiatry. 2007;164(6):942-948.
Rizzo V, Memmi M, Moratti R, Melzi d’Eril G, Perucca E. Concentrations of L-dopa in plasma and plasma ultrafiltrates. J. Pharm. Biomed. Anal. 1996;14(8-10):1043-1046.
Rosol TJ, Yarrington JT, Latendresse J, Capen CC. Adrenal gland: structure, function, and mechanisms of toxicity. Toxicol. Pathol. 2001;29(1):41-48.
State of the science of endocrine disrupting chemicals. Bergman A, Heindel J, Jobling S, Kidd K, Zoeller RT. UNEP/WHO, 2013. P. 10.
Vandenberg LN, Colborn T, Hayes TB, Heindel JJ, Jacobs DR Jr, Lee DH, Shioda T, Soto AM, vom Saal FS, Welshons WV, Zoeller RT, Myers JP. Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses. Endocr. Rev. 2012;33(3):378-455.
Wurtman RJ. Stress and the adrenocortical control of epinephrine synthesis. Metabolism. 2002;51(6, Suppl. 1):11-14.
Zala SM, Penn DJ. Abnormal behaviours induced by chemical pollution: a review of the evidence and new challenges. Anim. Behav. 2004;68(4):649-664.
Zoeller RT, Rovet J. Timing of thyroid hormone action in the developing brain: clinical observations and experimental findings. J. Neuroendocrinol. 2004;16(10):809-818.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 163, No. 4, pp. 415-418, April, 2017
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Yaglova, N.V., Tsomartova, D.A. & Yaglov, V.V. Effect of Prenatal and Postnatal Exposure to Low Doses of DDT on Catecholamine Secretion in Rats in Different Period of Ontogeny. Bull Exp Biol Med 163, 422–424 (2017). https://doi.org/10.1007/s10517-017-3819-6
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DOI: https://doi.org/10.1007/s10517-017-3819-6