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Anticonvulsant Effects of Combined Treatment with Citicoline and Valproate on the Model of Acute Generalized Convulsions Induced by Pentylenetetrazole in Wistar Rats

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We studied anticonvulsant effects of combined treatment with citicoline, a nootropic substance with neuroregenerative and neuroprotective activities, and valproate, an antiepileptic agent widely used in the treatment of epilepsy, on the model of pentylenetetrazole-induced (75 mg/kg, intraperitoneally) acute generalized convulsions in male Wistar rats. Combined treatment with citicoline and valproate in minimum effective doses (70 and 300 mg/kg, respectively) potentiated the anticonvulsant properties of both agents.

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Authors and Affiliations

  1. Research Institute of General Pathology and Pathophysiology, Moscow, Russia

    M. N. Karpova, L. V. Kuznetsova & N. V. Klishina

  2. Department of Psychiatry, Addiction Medicine, and Medical Psychology, Tver’ State Medical Academy, Ministry of Health of the Russian Federation, Tver’, Russia

    K. A. Zin’kovskii

Authors
  1. M. N. Karpova
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  2. L. V. Kuznetsova
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  3. K. A. Zin’kovskii
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  4. N. V. Klishina
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Corresponding author

Correspondence to M. N. Karpova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 160, No. 10, pp. 425-428, October, 2015

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Karpova, M.N., Kuznetsova, L.V., Zin’kovskii, K.A. et al. Anticonvulsant Effects of Combined Treatment with Citicoline and Valproate on the Model of Acute Generalized Convulsions Induced by Pentylenetetrazole in Wistar Rats. Bull Exp Biol Med 160, 429–431 (2016). https://doi.org/10.1007/s10517-016-3188-6

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  • DOI: https://doi.org/10.1007/s10517-016-3188-6

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