Specific features of diffusion in the cerebral corticospinal tract of patients with early stages of schizophrenia were studied using methods of diffusion tensor magnetic-resonance imaging and magnetic resonance spectroscopy. A decrease in the coefficient of fractional anisotropy in the posterior limb of the internal capsule and an increase in diffusion coefficient in the radiate crown and motor cortex were observed. The results reflect different mechanisms of changes in water diffusion in various areas of the corticospinal tract: changes in nerve fiber microstructure in the internal capsule of the left hemisphere and a decrease in their density in the motor cortex and radiate crown.
Similar content being viewed by others
References
V. I. Kozlov and T. A. Tsekhmistrenko, Anatomy of Nervous System [in Russian], Moscow (2006), pp. 374-381.
M. V. Ublinskii, N. A. Semenova, T. A. Akhadov, et al., Dokl. Akad. Nauk, 453, No. 2, 218 (2013).
M. V. Ublinskii, N. A. Semenova, O. V. Lukovkina, et al., Bull. Exp. Biol. Med., 158, No. 5, 611-613 (2015).
N. Barnea-Goraly, V. Menon, M. Eckert, et al., Cereb. Cortex, 15, No. 12, 1848-1854 (2005).
T. J. Crow, Schizoph. Res., 30, No. 2, 111-114 (1998).
G. Douaud, S. Smith, M. Jenkinson, et al., Brain, 130, Pt. 9, 2357-2386 (2007).
K. J. Friston, S. Herold, D. Silbersweig, et al., Br. J. Psychiatry, 167, No. 3, 343-349 (1995).
M. S. Gazzaniga, Brain, 123, Pt. 7, 1293-1326 (2000).
P. K. McGuire, D. A. Silbersweig, I. Wright, et al., Br. K. Psychiatry, 169, No. 2, 148-159 (1996).
J. S. Oh, M. Kubicki, G. Rosenberger, et al., Hum. Brain Mapp., 30, No. 11, 3812-3825 (2009).
C. Pierpaoli, P. Jezzard, P. J. Basser, et al., Radiology, 201, No. 3, 305-312 (1996).
A. Ruef, L. Curtis, G. Moy, et al., J. Psychiatry Neurosci., 37, No. 5, 305-312 (2012).
V. J. Schmithorst, M. Wilke, B. J. Dardzinski, and S. K. Holland, Radiology, 222, No. 1, 212-218 (2002).
D. R. Weinberger, K. F. Berman, R. Suddath, and E. F. Torrey, Am. J. Psychiatry, 149, No. 7, 890-897 (1992).
S. S. Yeo, M. C. Chang, Y. H. Kwon, et al., Neurosci. Lett., 508, No. 1, 9-12 (2012).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 159, No. 1, pp. 36-39, January, 2015
Rights and permissions
About this article
Cite this article
Ublinskii, M.V., Semenova, N.A., Lukovkina, O.V. et al. Characteristics of Diffusion in the Corticospinal Tract of Patients with Early Stage of Schizophrenia: Diffusion Tensor Magnetic Resonance Imaging. Bull Exp Biol Med 159, 29–31 (2015). https://doi.org/10.1007/s10517-015-2881-1
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-015-2881-1