We compared hemostimulating activity of glycyram and a preparation of D-glucuronic acid on the model of granulocytic hemopoiesis suppressed by 5-fluorouracil. Different mechanisms were shown to underlie activation of hemopoiesis by the above preparations: D-glucuronic acid directly affects hemopoietic cells, while glycyram modulates local mechanisms regulating hemopoiesis.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 155, No. 2, pp. 170-175, February, 2013
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Dygai, A.M., Zhdanov, V.V., Miroshnichenko, L.A. et al. Mechanisms of Stimulating Effect of Glycyram and D-Glucuronic Acid on Granulocytopoiesis Suppression by 5-Fluorouracil. Bull Exp Biol Med 155, 207–211 (2013). https://doi.org/10.1007/s10517-013-2114-4
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DOI: https://doi.org/10.1007/s10517-013-2114-4