In experiments on rat aortic ring segments, lysophosphatidylcholine in concentrations of 2 × 10−6, 2 × 10−5, and 2 × 10−4 M did not suppress the tonotropic effect of phenylephrine (6 × 10−6 and 6 × 10−5 M) and in concentration of 2 × 10−5 M even potentiated it, which was noted for phenylephrine at a concentration of 6 × 10−6 M. It was concluded that the chemomodulating effect of lysophosphatidylcholine depends on the type of receptors and cells.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
S. Glantz, Biomedical Statistics [Russian translation], Moscow (1999).
R. Y. Kashin, A. D. Nozdrachev, and V. I. Tsirkin, Vestn. SPbGU, Ser. 3, Issue 1, 55–71 (2010).
A. A. Kunshin, V. I. Tsirkin, and N. V. Prokazova, Byull. Eksp. Biol. Med., 143, No. 6, 4–7 (2007).
Y. A. Penkina, A. D. Nozdrachev, and V. I. Tsirkin, Vestn. SPbGU, Ser. 3, Issue 1, 55–68 (2008).
N. V. Prokazova, N. D. Zvezdina, and A. A. Korotaeva, Biokhimia, 63, No. 1, 38–46 (1998).
N. V. Prokazova, N. D. Zvezdina, I. V. Suslova, et al., Ros. Fiziol. Zh., 84, No. 10, 969–978 (1998).
E. N. Sizova and V. I. Tsirkin, Physiological Characterization of Endogenous Modulators of β-Adrenergic and Muscarinic Cholinergic Reactivity [in Russian], Kirov (2006).
V. I. Tsirkin, S. A. Dvoryansky, A. D. Nozdrachev, et al., Dokl. Akad. Nauk, 352, No. 1, 124–126 (1997).
T. Matsumoto, T. Kobayashi, and K. Kamata, Br. J. Pharmacol., 149, No. 7, 931–941 (2006).
N. K. Menon, J. Pataricza, M. Zehetgruber, and R. J. Bing, Life Sci., 47, No. 21, 1941–1948 (1990).
H. Suenaga and K. Kamata, Eur. J. Pharmacol., 378, No. 2, 177–186 (1999).
Y. Tang, R. Lu, Y. J. Li, et al., Zhongguo Yao Li Xue Bao, 18, No. 5, 405–407 (1997).
T. D. Vuong, S. de Kimpe, R. de Roos, et al., Kidney Int., 60, No. 3, 1088–1096 (2001).
R. Zhang, B. Rodrigues, and K. M. MacLeod, J. Pharmacol. Exp. Ther., 317, No. 1, 355–361 (2006).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 151, No. 7, pp. 18–21, July, 2011
Rights and permissions
About this article
Cite this article
Samodelkina, E.O., Tsirkin, V.I. & Prokazova, N.V. Effect of Lysophosphatidylcholine on α-Adrenoreactivity of Rat Aorta Smooth Muscles. Bull Exp Biol Med 152, 15–18 (2011). https://doi.org/10.1007/s10517-011-1441-6
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-011-1441-6