Abstract
Experiments on smooth muscles of rat stomach showed that lysophosphatidylcholine in concentrations of 10−8 and 10−7 g/ml does not modulate the tonotropic effect of acetylcholine (10−6 g/ml), in a concentration of 10−6 g/ml potentiated this effect (similarly to phosphatidylcholine, 10−6 g/ml), and reduced it in concentrations of 10−5−10−4 g/ml (similarly to hen egg yolk in dilutions of 1:500, 1:100, and 1:500). These data indicate that lysophosphatidylcholine modifies signal transduction from the receptor to G protein.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 143, No. 6, pp. 604–607, June, 2007
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Kunshin, A.A., Tsyrkin, V.I. & Prokazova, N.V. Influence of lysophosphatidylcholine, phosphatidylcholine, and hen egg yolk on contractile effects of acetylcholine on smooth muscles of rat stomach. Bull Exp Biol Med 143, 663–666 (2007). https://doi.org/10.1007/s10517-007-0208-6
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DOI: https://doi.org/10.1007/s10517-007-0208-6