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Monoaminergic Regulation of Hemopoiesis under Extreme Conditions

  • General Pathology and Pathological Physiology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

The role of the adrenergic, dopaminergic, and serotoninergic systems in the regulation of hemopoiesis was evaluated on various models of pathological processes (restraint stress, experimental neurosis, and cytostatic treatment). The proliferation, differentiation, and maturation of polypotent, multipotent, partially determined, and oligopotent hemopoietic precursors and functional activity of microenvironmental cells (stromal cells, macrophages, and Thy1,2+ cells) were shown to be under the control of a complex system of monoaminergic regulation. Central monoamines have a direct or indirect (mediated by microenvironmental cells) regulatory effect on hemopoietic precursors of various classes, which is realized via specific receptors. The system of colony-stimulating factors is characterized by selective sensitivity to catecholamines. It should be emphasized that the effects of erythropoietin are mainly associated with serotonin. Irrespective of experimental conditions (hyperplasia of hemopoiesis, myelosuppression, and dysregulation of precursor cell proliferation and differentiation), the erythroid hemopoietic stem is more sensitive to serotoninergic influences. Granulocytopoiesis was revealed to be more sensitive to central catecholamines.

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References

  1. M. B. Belogurova, Prakticheskaya Onkologiya, 4, No. 3, 183-190 (2003).

    Google Scholar 

  2. A. I. Vorob’ev, Manual of Hematology [in Russian], In Three Volumes, Moscow (2002), Vol. 1.

  3. T. A. Voronina, Yu. I. Vikhlyaeva, and L. N. Nerobokova, Phenazepam, Ed. A. V. Bogatskii [in Russian], Kiev (1982), pp. 87-169.

  4. T. A. Voronina and S. B. Seredenin, Manual on Experimental (Preclinical) Study of New Pharmacological Agents [in Russian], Moscow (2000), pp. 126-130.

  5. E. D. Goldberg, A. M. Dygai, and V. V. Zhdanov, Med. Immunol., 3, No. 4, 487-498 (2001).

    Google Scholar 

  6. E. D. Goldberg, A. M. Dygai, and V. V. Zhdanov, Role of the Hemopoiesis-Inducing Microenvironment in Regulation of Hemopoiesis during Cytostatic-Induced Myelosuppressions [in Russian], Tomsk (1999).

  7. E. D. Goldberg, A. M. Dygai, V. V. Zhdanov, and V. E. Goldberg, Byull. Eksp. Biol. Med., Suppl. 3, 5-15 (2001).

    Google Scholar 

  8. E. D. Goldberg, A. M. Dygai, V. V. Zhdanov, and I. A. Khlusov, Ibid., 127, No. 5, 484-494 (1999).

    CAS  Google Scholar 

  9. E. D. Goldberg, A. M. Dygai, V. V. Zhdanov, et al., Ibid., Suppl. 2, 6-13 (2008).

  10. E. D. Goldberg, A. M. Dygai, V. V. Zhdanov, et al., Pharmacological Regulation of Hemopoiesis during Experimental Neuroses [in Russian], Tomsk (2007).

  11. E. D. Goldberg, A. M. Dygai, N. V. Provalova, et al., Role of the Nervous System in Regulation of Hemopoiesis [in Russian], Tomsk (2004).

  12. E. D. Goldberg, A. M. Dygai, and E. G. Skurikhin, Byull. Sib. Med., 5, No. 2, 16-22 (2006).

    Google Scholar 

  13. E. D. Goldberg, A. M. Dygai, E. G. Skurikhin, et al., Byull. Eksp. Biol. Med., 129, No. 4, 381-385 (2000).

    Google Scholar 

  14. E. D. Goldberg, A. M. Dygai, E. G. Skurikhin, et al., Ibid., 147, No. 7, 56-59 (2009).

    Google Scholar 

  15. E. D. Goldberg, A. M. Dygai, E. G. Skurikhin, et al., Method for a Study of Hemopoiesis Taking into Account Specific Features of Higher Nervous Activity, Inventor’s Certificate (RU) No. 2317541, Byull. No. 5. 20.02.08.

  16. E. D. Goldberg, A. M. Dygai, N. I. Suslov, et al., Byull. Sib. Otd. Ros. Akad. Med. Nauk, No. 1, 129-134 (1998).

  17. E. D. Goldberg, A. M. Dygai, N. I. Suslov, et al., Dysregulation Pathology of the Blood System, Eds. E. D. Goldberg and G. N. Kryzhanovskii [in Russian], Moscow (2009), pp. 275-303.

  18. E. D. Goldberg, A. M. Dygai, and I. A. Khlusov, Role of the Autonomic Nervous System in Regulation of Hemopoiesis [in Russian], Tomsk (1997).

  19. E. D. Goldberg, A. M. Dygai, and V. P. Shakhov, Tissue Culture Methods in Hematology [in Russian], Tomsk (1992).

  20. E. D. Goldberg, A. M. Dygai, and E. Yu. Sherstoboev, Mechanisms for Local Regulation of Hemopoiesis [in Russian], Tomsk (2000).

  21. E. D. Goldberg and E. G. Skurikhin, Pathophysiology of Mental Disorders, Eds. V. Ya. Semke and F. Lang [in Russian], Tomsk (2006).

  22. A. M. Dygai, V. V. Zhdanov, M. Yu. Minakova, and E. D. Goldberg, Byull. Eksp. Biol. Med., 124, No. 8, 161-165 (1997).

    CAS  Google Scholar 

  23. A. M. Dygai and N. A. Klimenko, Infl ammation and Hemopoiesis [in Russian], Tomsk (1992).

  24. A. M. Dygai and O. V. Pershina, Pathophysiology of Mental Disorders, Eds. V. Ya. Semke and F. Lang [in Russian], Tomsk (2006).

  25. A. M. Dygai, E. G. Skurikhin, T. V. Andreeva, et al., Byull. Eksp. Biol. Med., 148, No. 3, 255-260 (2010).

    Google Scholar 

  26. A. M. Dygai, E. G. Skurikhin, O. V. Pershina, et al., Ibid., 148, No. 4, 400-404 (2010).

    Google Scholar 

  27. A. M. Dygai, E. G. Skurikhin, O. V. Pershina, et al., Ibid., 147, No. 5, 540-543 (2009).

    Google Scholar 

  28. A. M. Dygai, E. G. Skurikhin, O. V. Pershina, et al., Ibid., 145, No. 4, 383-388 (2008).

    Google Scholar 

  29. A. M. Dygai, E. G. Skurikhin, O. V. Pershina, et al., Eksper. Klin. Farmakol., Suppl., 14 (2010).

  30. A. M. Dygai, E. G. Skurikhin, N. V. Provalova, and N. I. Suslov, Byull. Eksp. Biol. Med., 133, No. 1, 17-21 (2002).

    Article  Google Scholar 

  31. A. M. Dygai, E. G. Skurikhin, N. I. Suslov, et al., Ibid., 126, No. 12, 628-631 (1998).

    CAS  Google Scholar 

  32. A. M. Dygai, N. I. Suslov, E. G. Skurikhin, and A. A. Churin, Ibid., 123, No. 2, 158-161 (1997).

    CAS  Google Scholar 

  33. A. M. Dygai and V. P. Shakhov, Role of Cell-to-Cell Interactions in the Regulation of Hemopoiesis [in Russian], Tomsk (1989).

  34. A. M. Dygai, E. Yu. Sherstoboev, and E. D. Goldberg, Byull. Eksp. Biol. Med., 125, No. 4, 374-377 (1998).

    Article  CAS  Google Scholar 

  35. V. V. Zhdanov, S. G. Aksinenko, A. M. Dygai, and E. D. Goldberg, Ibid., 125, No. 5, 509-513 (1998).

    CAS  Google Scholar 

  36. Yu. M. Zakharov, Ros. Fiziol. Zh., 90, No. 8, 987-1000 (2004).

    Google Scholar 

  37. V. M. Koval’zon, Vestn. Biol. Psikhiatr., No. 3, 3-6 (2003).

  38. M. Yu. Minakova, Monoaminergic Mechanisms for Regulation of Hemopoiesis during Cytostatic-Induced Myelosuppressions [in Russian], Doct. Med. Sci. Dissertation, Tomsk (2009).

  39. M. Yu. Minakova, E. G. Skurikhin, and O. V. Pershina, Byull. Eksp. Biol. Med., Suppl. 1, 79-86 (2007).

  40. M. Yu. Minakova, E. G. Skurikhin, O. V. Pershina, and E. V. Udut, Ibid., Suppl. 1, 86-91 (2007).

  41. N. I. Perevodchikova, Manual of Chemotherapy for Tumor Diseases [in Russian], Moscow (2005).

  42. O. V. Pershina, Mechanisms for Individual Differences in Blood Reactions during Experimental Neuroses [in Russian], Doct.Med. Sci. Dissertation, Tomsk (2006).

  43. O. V. Pershina, E. G. Skurikhin, and A. M. Dygai, Byull. Eksp. Biol. Med., 144, No. 8, 124-127 (2007).

    Google Scholar 

  44. O. V. Pershina, E. G. Skurikhin, L. A. Stavrova, et al., Ibid., 138, No. 11, 499-505 (2004).

    Google Scholar 

  45. O. V. Pershina, E. G. Skurikhin, and N. I. Suslov, Eksper. Klin. Farmakol., 68, No. 4, 16-18 (2005).

    CAS  Google Scholar 

  46. E. G. Skurikhin, Mechanisms for the Regulation of Hemopoiesis during Experimental Neuroses [in Russian], Doct. Med. Sci. Dissertation, Tomsk (2004).

  47. E. G. Skurikhin, Reactions of the Blood System, Behavioral Disturbances, and Mechanisms for These Changes during Experimental Neurosis [in Russian], Cand. Med. Sci. Dissertation, Tomsk (1997).

  48. E. G. Skurikhin, A. M. Dygai, N. V. Provalova, et al., Byull. Eksp. Biol. Med., 139, No. 5, 495-501 (2005).

    Article  Google Scholar 

  49. E. G. Skurikhin, A. M. Dygai, N. I. Suslov, et al., Ibid., 131, No. 1, 43-47 (2001).

    Google Scholar 

  50. E. G. Skurikhin, M. Yu. Minakova, O. V. Pershina, et al., Ibid., 144, No. 9, 253-259 (2007).

    Google Scholar 

  51. E. G. Skurikhin, O. V. Pershina, N. N. Ermakova, et al., Eksper. Klin. Farmakol., 73, No. 3, 21-24 (2010).

    CAS  Google Scholar 

  52. E. G. Skurikhin, O. V. Pershina, and M. Yu. Minakova, Kletochn. Tekhnol. Biol. Med., No. 4, 247-253 (2005).

  53. E. G. Skurikhin, O. V. Pershina, M. Yu. Minakova, et al., Byull. Eksp. Biol. Med., 145, No. 10, 385-390 (2008).

    Google Scholar 

  54. E. G. Skurikhin, O. V. Pershina, M. Yu. Minakova, et al., Ibid., 141, No. 6, 616-621 (2006).

    Google Scholar 

  55. E. G. Skurikhin, O. V. Pershina, M. Yu. Minakova, et al., Ibid., 143, No. 5, 501-507 (2007).

    Google Scholar 

  56. E. G. Skurikhin, O. V. Pershina, N. V. Provalova, et al., Ibid., Suppl. 1, 14-20 (2005).

  57. E. G. Skurikhin, O. V. Pershina, L. A. Stavrova, et al., Ibid., 140, No. 8, 136-141 (2005).

    Google Scholar 

  58. E. G. Skurikhin, O. V. Pershina, N. I. Suslov, et al., Ibid., 139, No. 6, 608-612 (2005).

    Google Scholar 

  59. E. G. Skurikhin, N. V. Provalova, O. V. Pershina, and M. Yu. Mi nakova, Kletochn. Tekhnol. Biol. Med., No. 4, 220-225 (2005).

    Google Scholar 

  60. E. G. Skurikhin, N. I. Suslov, N. V. Provalova, et al., Byull. Eksp. Biol. Med., Suppl. 1, 7-11 (1999).

  61. E. G. Skurikhin, E. S. Khmelevskaya, O. V. Pershina, et al., Kletochn. Tekhnol. Biol. Med., No. 3, 127-132 (2010).

  62. I. A. Khlusov, A. M. Dygai, and E. D. Goldberg, Byull. Eksp. Biol. Med., 123, No. 6, 638-641 (1997).

    Article  CAS  Google Scholar 

  63. I. L. Chertkov and A. Fridenshtein, Manual of Physiology. Physiology of the Blood System [in Russian], Leningrad (1979).

  64. A. M. Afan, C. S. Broome, S. E. Nicholls, et al., Br. J. Haematol., 98, No. 3, 569-577 (1997).

    Article  PubMed  CAS  Google Scholar 

  65. J. E. Brown and J. W. Adamson, Cell Tissue Kinet., 10, No. 3, 289-298 (1977).

    PubMed  CAS  Google Scholar 

  66. J. W. Byron, Cell Cycle Controls, Eds. G. M. Padilles et al., New York (1974), pp. 97-99.

  67. P. Crocker and S. Gordon, J. Exp. Med., 162, No. 3, 993-1014 (1985).

    Article  PubMed  CAS  Google Scholar 

  68. A. M. Dygai, I. A. Khlusov, V. V. Udut, et al., Pathophysiology, 4, 175-181 (1997).

    Article  CAS  Google Scholar 

  69. J. A. Glaspy, Oncology (Williston Park), 17, No. 11, 1593-1603 (2003).

    Google Scholar 

  70. E. D. Goldberg and A. M. Dygai, Hematol. Rev., 4, 11-67 (1992).

    Google Scholar 

  71. S. Imai, Y. Tokunaga, T. Maeda, et al., J. Orthop. Res., 15, No. 1, 133-140 (1997).

    Article  PubMed  CAS  Google Scholar 

  72. A. Iwasaki, K. Inoue, and S. Hukuda, Clin. Exp. Rheumatol., 13, No. 2, 173-178 (1995).

    PubMed  CAS  Google Scholar 

  73. D. Jouvet, P. Vimont, F. Delorme, and M. Jouvet, C. R. Seances Soc. Biol. Fil., 158, 756-759 (1964).

    PubMed  CAS  Google Scholar 

  74. J. Mladenovic and J. W. Adamson, Br. J. Haematol., 56, No. 2, 323-332 (1984).

    Article  PubMed  CAS  Google Scholar 

  75. A. Morley, P. Quesenberry, M. Garrity, et al., Proc. Soc. Exp. Biol. Med., 138, No. 1, 57-59 (1971).

    PubMed  CAS  Google Scholar 

  76. L. Sensebe, M. Deschaseaux, J. Li, et al., Stem Cells, 15, No. 2, 133-143 (1997).

    Article  PubMed  CAS  Google Scholar 

  77. M. S. Setchenska, S. A. Bonanou-Tzedaki, and H. R. Arnstein, Biochem. Pharmacol., 35, No. 21, 3679-3684 (1986).

    Article  PubMed  CAS  Google Scholar 

  78. Z. Tabarowski, K. Gibson-Berry, and S. Y. Felten, Acta Histochem., 98, No. 4, 453-457 (1996).

    PubMed  CAS  Google Scholar 

  79. Y. Tang, R. Shancar, R. Gamelli, and S. Jones, J. Neuroimmunol., 96, No. 2, 182-189 (1999).

    Article  PubMed  CAS  Google Scholar 

  80. R. Tordjman, N. Ortega, L. Coulombel, et al., Blood, 94, No. 7, 2301-2309 (1999).

    PubMed  CAS  Google Scholar 

  81. T. Vial and J. Descotes, Drug Saf., 13, No. 6, 371-406 (1995).

    Article  PubMed  CAS  Google Scholar 

  82. E. Weihe, D. Nohr, S. Michel, et al., Int. J. Neurosci., 59, Nos. 1-3, 1-23 (1991).

    Article  PubMed  CAS  Google Scholar 

  83. K. Yamazaki and T. D. Allen, Am. J. Anat., 187, No. 3, 261-276 (1990).

    Article  PubMed  CAS  Google Scholar 

  84. N. R. Zahniser, C. M. Bier-Laning, J. G. Gerber, and A. S. Nies, Clin. Pharmacol. Ther., 45, No. 5, 469-475 (1989).

    Article  PubMed  CAS  Google Scholar 

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  1. Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia

    A. M. Dygai & E. G. Skurikhin

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  1. A. M. Dygai
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  2. E. G. Skurikhin
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Correspondence to A. M. Dygai.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 151, No. 2, pp. 132-139, February, 2011

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Dygai, A.M., Skurikhin, E.G. Monoaminergic Regulation of Hemopoiesis under Extreme Conditions. Bull Exp Biol Med 151, 171–178 (2011). https://doi.org/10.1007/s10517-011-1282-3

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