In vitro experiments showed that stem and cancer cells retained their viability on the surface of porous silicon with 10-100 nm nanostructures, but their proliferation was inhibited. Silicon nanoparticles of 100 nm in size obtained by mechanical grinding of porous silicon films or crystal silicon plates in a concentration below 1 mg/ml in solution did not modify viability and proliferation of mouse fibroblast and human laryngeal cancer cells. Additional ultrasonic exposure of cancer cells in the presence of 1 mg/ml silicon nanoparticles added to nutrient medium led to complete destruction of cells or to the appearance of membrane defects blocking their proliferation and initiating their apoptotic death.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 151, No. 1, pp. 91-95, January, 2011
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Osminkina, L.A., Luckyanova, E.N., Gongalsky, M.B. et al. Effects of Nanostructurized Silicon on Proliferation of Stem and Cancer Cell. Bull Exp Biol Med 151, 79–83 (2011). https://doi.org/10.1007/s10517-011-1264-5
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DOI: https://doi.org/10.1007/s10517-011-1264-5