Spontaneous and induced apoptosis of neutrophils and lymphocytes was studied in alcoholics during the abstinent syndrome and in healthy individuals. In alcoholics, the levels of lymphocyte and neutrophil apoptosis at the receptor and cellular levels were higher than in healthy subjects. Blood cells from alcohol addicts and normal individuals similarly react to stimuli (hyperthermia and synthetic glucocorticoid prednisolone) in vitro.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
I. P. Anokhina, N. N. Ivanets, and V. Ya. Drobysheva, Vestn. Rossiisk. Akad. Med. Nauk, No. 7, 29-37 (1998).
P. S. Barban, R. A. Pshenichnov, A. N. Pantyukhina, et al., Immunofl uorescent Analysis, Sverdlovsk (1988).
N. A. Bokhan and V. D. Prokopyeva, Molecular Mechanisms of Effects of Ethanol and Its Metabolites on Erythrocytes In Vitro and In Vivo [in Russian], Tomsk (2004).
S. A. Ivanova, T. P. Vetlugina, N. A. Bokhan, and O. I. Epstein, Sibirsk. Vestn. Psikhiatr. Narkol., No. 1, 52-60 (2002).
I. N. Moroz and S. N. Teplova, Ibid., No. 1, 33-36 (2003).
A. A. Fil’chenkov and R. S. Stoika, Apoptosis and Cancer [in Russian], Kiev (1999).
P. J. Brooks, Neurochem. Int., 37, Nos. 5-6, 403-425 (2000).
J. Fernandez-Sola, J. M. Nicolas, F. Fatjo, et al., Hum. Pathol., 34, No. 12, 1247-1252 (2003).
M. E. Jung, M. B. Gatch, and J. W. Simpkins, Exp. Biol. Med. (Maywood), 230, No. 1, 8-22 (2005).
J. H. Hu, J. Jiang, Y. H. Ma, et al., Cell Res., 13, No. 5, 361-367 (2003).
T. Nakahara, K. Hashimoto, M. Hirano, et al., Am. J. Physiol. Endocrinol. Metab., 285, No. 6, E1273-E1281 (2003).
D. A. Rodriguez, C. Moncada, M. T. Nunez, et al., Alcohol., 33, No. 1, 9-15 (2004).
K. Sharma, R. X. Wang, L. Y. Zhang, et al., Pharmacol. Ther., 88, No. 3, 333-347 (2000).
D. Wu, Q. Zhai, and X. Shi, J. Gastroenterol. Hepatol., 21, Suppl., S26-S29 (2006).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 149, No. 2, pp. 209-212, February, 2010
Rights and permissions
About this article
Cite this article
Ivanova, S.A., Vyalova, N.M., Zhernova, E.V. et al. Spontaneous and In Vitro Induced Apoptosis of Lymphocytes and Neutrophils in Patients with Alcohol Dependence. Bull Exp Biol Med 149, 246–249 (2010). https://doi.org/10.1007/s10517-010-0918-z
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-010-0918-z