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The Intensity of Blood Lymphocyte Apoptosis in Chronically Exposed Individuals with Obligate Forms of Precancerous Conditions

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Bulletin of Experimental Biology and Medicine Aims and scope

We studied the apoptotic death of peripheral blood lymphocytes in individuals chronically exposed to radiation with a history of obligate forms of precancerous conditions. The study included 242 subjects chronically exposed to low-intensity radiation in the range of low and medium doses (mean dose of irradiation of the red bone marrow 555±39 mGy). Of these, 121 subjects had obligate forms of precancerous conditions. In irradiated individuals with obligate forms of precancers, a statistically significant increase in the frequency of apoptosis of peripheral blood lymphocytes at an early and late stages was revealed. Correlation analysis revealed no dependence of the apoptotic death of peripheral blood lymphocytes on the dose of red bone marrow irradiation.

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Authors and Affiliations

  1. Urals Research Center for Radiation Medicine, Federal Medical-Biological Agency of Russia, Chelyabinsk, Russia

    E. A. Blinova, A. I. Kotikova & A. V. Akleev

  2. Chelyabinsk State University, Chelyabinsk, Russia

    E. A. Blinova & A. V. Akleev

Authors
  1. E. A. Blinova
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  2. A. I. Kotikova
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  3. A. V. Akleev
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Correspondence to E. A. Blinova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 176, No. 8, pp. 233-236, August, 2023

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Blinova, E.A., Kotikova, A.I. & Akleev, A.V. The Intensity of Blood Lymphocyte Apoptosis in Chronically Exposed Individuals with Obligate Forms of Precancerous Conditions. Bull Exp Biol Med 176, 202–204 (2023). https://doi.org/10.1007/s10517-024-05995-3

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  • DOI: https://doi.org/10.1007/s10517-024-05995-3

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