Abstract
We studied the effect of tripeptide T-38 (Lys-Glu-Asp) in the presence of cyclophosphamide on cell proliferation and apoptosis in explants of splenic lymphoid tissue from young and old rats. Peptide T-38 in a concentration of 0.05 ng/ml produced a stimulatory effect on the growth zone of the explants. Addition of 1 mg/ml cyclophosphamide to the culture medium suppressed cell proliferation, which was associated with enhanced expression of proapoptotic p53 protein. Under conditions of combined treatment with cyclophosphamide and T-38 no inhibiting effect of the cytostatics was observed. Thus, tripeptide T-38 in the presence of cytostatics produces a protective effect on cell proliferation in lymphoid tissue explants.
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Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 145, No. 6, pp. 695–698, June, 2008
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Chalisova, N.I., Lesnyak, V.V., Oganezova, E.V. et al. Protective effect of tripeptide in the presence of cyclophosphamide on the growth of cultured lymphoid tissue from rats of different age. Bull Exp Biol Med 145, 748–750 (2008). https://doi.org/10.1007/s10517-008-0189-0
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DOI: https://doi.org/10.1007/s10517-008-0189-0