Abstract
We studied the safety and efficiency of transplantation of autologous bone marrow cells in complex therapy of patients with spinal cord injury in the late period of the disease. In control group patients, meningomyeloradiculolis was performed, while in the main group surgical treatment was supplemented by transplantation of autologous bone marrow cells. Transplantation of BM stem cells into the cyst cavity and intravenously was well tolerated, did not cause allergic or inflammatory reactions in the early and delayed periods after surgery, and did not induce the formation of ossification foci in the nervous tissue. Analysis of the neurological status by ASIA, Bartel, and Ashworth scales showed that in the main group the positive clinical dynamics was more often observed than in the control. The decrease in neurological deficit included improvement of sensory and motor activity and conducting sensory function. Thus, transplantation of autologous bone marrow cells can be a novel safe strategy for the treatment of patients in the late period after spinal trauma.
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References
M. A. Kosichkin, L. P. Grishina, and D. M. Shapiro, Medical and Social Examination and Rehabilitation [in Russian], No. 1 (1999).
D. S. Stankov, P. I. Katunyan, M. E. Krasheninnikov, and N. A. Onishchenko, Vestn. Transplantol. Iskusstven.Organ., No. 1, 44–52 (2003).
E. P. Chernykh, E. Ya. Shevela, O. Yu. Leplina, et al., Kletochn. Tekhnol. Biol. Med., No. 1, 8–11 (2006).
M. B. Bracken and T. R. Holford, J. Neurosurg. Spine, 96,Suppl. 3, 259–266 (2002).
J. Chen, P. R. Sanberg, Y. Li, et al., Stroke, 32, No. 11, 2682–2688 (2001).
M. Chopp, X. H. Zhang, Y. Li, et al., Neuroreport., 11, 3001–3005 (2000).
S. orti, F. Locatelli1, S. Strazzer, et al., Cur. Gene Ther., 3, 247–272 (2003).
C. P. Hofstetter, E.J. Schwarz, D. Hess, et al., Proc. Natl. Acad. Sci. USA, 99, No. 4, 2199–2204 (2002).
C. E. Hulsebosch, Adv. Physiol. Educ., 26, Nos. 1–4, 238–255 (2002).
M. Korbling and Z. Estrov, N. Engl. J. Med., 349, Nos. 6, 570–582 (2003).
H. C. Park, Y. S. Shims, Y. Ha, et al., Tissue Eng., 11, No. 5–6, 913–922 (2005).
P. J. Reier, NeuroRx., 1, No. 4, 424–451 (2004).
S. S. Schultz, Current Drug Targets., 6, No. 1, 63–73 (2005).
C. N. Svendsen, M. A. Caldwell, and T. Ostenfeld, Brain Pathol., 9, 499–513 (1999).
E. Sykova, P. Jendelova, L. Urdzýkova, et al., Cell. Mol. Neurobiol., 26, No. 7–8, 1111–1127 (2006).
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Translated from Kletochnye Tehnologii v Biologii i Medicine, No. 2, pp. 109–114, April, 2007
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Chernykh, E.R., Stupak, V.V., Muradov, G.M. et al. Application of autologous bone marrow stem cells in the therapy of spinal cord injury patients. Bull Exp Biol Med 143, 543–547 (2007). https://doi.org/10.1007/s10517-007-0175-y
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DOI: https://doi.org/10.1007/s10517-007-0175-y