Abstract
We studied structural reorganization of the liver after toxic injury caused by a single injection of doxorubicin in a sublethal dose (10 mg/kg). The morphogenesis of doxorubicin injury to the liver is determined by two main pathogenetic factors: cytotoxic effect of doxorubicin and its metabolites on liver cell populations (primarily hepatocytes) and pronounced hemodynamic disorders in the greater circulation resuling from the development of chronic cardiac insufficiency. Changes in hepatocyte caused by doxorubicin manifest by fatty degeneration in the periportal zones and by pronounced lytic changes in the pericentral zones, most pronounced by day 30 of the experiment. Doxorubicin in the studied dose exhibited no cytostatic effect on the hepatocyte population. Hepatocyte proliferation, observed during the entire experiment, leads to an appreciable increase in their count and liver weight.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
D. Valla, Ros. Zh. Gastroenterol., Gepatol., Kolonoproktol., No. 4, 67–69 (2001).
O. M. Drapkina, M. V. Maevskaya, Ya. A. Libet, et al., Ibid., No. 5, 87–91 (2003).
E. L. Lushnikova, M. G. Klinnikova, O. P. Molodykh, and L. M. Nepomnyashchikh, Byull. Eksp. Biol. Med., 138, No. 12, 684–689 (2004).
L. M. Nepomnyashchikh, E. L. Lushnikova, and D. E. Semenov, Regeneratory-Plastic Cardiac Insufficiency: Morphological Bases and Molecular Mechanisms [in Russian], Moscow (2003).
Ch. S. Pavlov, Yu. O. Shul'pekova, V. B. Zolotarevskii, and V. T. Ivashkin, Ros. Zh. Gastroenterol., Gepatol., Kolonoproktol., No. 2, 13–20 (2005).
A. J. Z. Garrido, A. C. Romo, and F. B. Padilla, Ann. Hepatol., 2, 47–51 (2003).
I. Grattagliano, P. Portincasa, V. O. Palmieri, and G. Palasciano, Ibid., 1, 162–168 (2002).
H. Jaeschke, G. J. Gores, A. I. Cederbaum, et al., Toxicol. Sci., 65, 166–176 (2002).
W. M. Lee, N. Engl. J. Med., 329, 862–872 (1993).
J. A. Oben, T. Roskams, S. Yang, et al., Gut, 53, 438–445 (2004).
H. Reynaert, M. G. Thompson, T. Thomas, and A. Geerts, Ibid., 50, 571–581 (2002).
J. Robert and L. Gianni, Cancer Surv., 17, 219–252 (1993).
F. Sierra and D. Torres, Ann. Hepatol., 3, 18–25 (2004).
Author information
Authors and Affiliations
Corresponding author
Additional information
__________
Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 141, No. 5, pp. 579–585, May, 2006
Rights and permissions
About this article
Cite this article
Molodykh, O.P., Lushnikova, E.L., Klinnikova, M.G. et al. Structural reorganization of the rat liver under cytotoxic effect of doxorubicin. Bull Exp Biol Med 141, 639–644 (2006). https://doi.org/10.1007/s10517-006-0241-x
Received:
Issue Date:
DOI: https://doi.org/10.1007/s10517-006-0241-x