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Role of CSL-dependent and independent Notch signaling pathways in cell apoptosis

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Abstract

Apoptosis is a normally biological phenomenon in various organisms, involving complexly molecular mechanisms with a series of signaling processes. Notch signaling is found evolutionarily conserved in many species, playing a critical role in embryonic development, normal tissue homeostasis, angiogenesis and immunoregulation. The focus of this review is on currently novel advances about roles of CSL-dependent and independent Notch signaling pathways in cell apoptosis. The CSL can bind Notch intracellular domain (NIC) to act as a switch in mediating transcriptional activation or inactivation of the Notch signaling pathway downstream genes in the nucleus. It shows that CSL-dependent signaling regulates the cell apoptosis through Hes-1-PTEN-AKT-mTOR signaling, but rather the CSL-independent signaling mediates the cell apoptosis possibly via NIC-mTORC2-AKT-mTOR signaling, providing a new insight into apoptotic mechanisms.

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Acknowledgments

This project was supported by the National Natural Science Foundation of China (Grant Numbers 30971465, 81172824) to F.Y. Xing.

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Authors and Affiliations

  1. Department of Immunobiology, Institute of Tissue Transplantation and Immunology, Jinan University, Guangzhou, 510632, China

    Chong Zeng & Feiyue Xing

  2. Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Jinan University, Guangzhou, 510632, China

    Chong Zeng & Feiyue Xing

  3. Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, 100084, China

    Rui Xing

  4. Department of Stomatology, Jinan University, Guangzhou, 510632, China

    Jing Liu

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  1. Chong Zeng
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Correspondence to Feiyue Xing.

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Zeng, C., Xing, R., Liu, J. et al. Role of CSL-dependent and independent Notch signaling pathways in cell apoptosis. Apoptosis 21, 1–12 (2016). https://doi.org/10.1007/s10495-015-1188-z

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