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Non-canonical activation of Notch signaling/target genes in vertebrates

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Abstract

Evolutionarily conserved Notch signaling orchestrates diverse physiological mechanisms during metazoan development and homeostasis. Classically, ligand-activated Notch receptors transduce the signaling cascade through the interaction of DNA-bound CBF1-co-repressor complex. However, recent reports have demonstrated execution of a CBF1-independent Notch pathway through signaling cross-talks in various cells/tissues. Here, we have tried to congregate the reports that describe the non-canonical/CBF1-independent Notch signaling and target gene activation in vertebrates with specific emphasis on their functional relevance.

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  1. Neuro-Stem Cell Biology Laboratory, Neurobiology Division, Rajiv Gandhi Centre for Biotechnology, Thycaud PO, Poojappura, Thiruvananthapuram, 695 014, Kerala, India

    Rajendran Sanalkumar, Sivadasan Bindu Dhanesh & Jackson James

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  1. Rajendran Sanalkumar
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  2. Sivadasan Bindu Dhanesh
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Correspondence to Jackson James.

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Sanalkumar, R., Dhanesh, S.B. & James, J. Non-canonical activation of Notch signaling/target genes in vertebrates. Cell. Mol. Life Sci. 67, 2957–2968 (2010). https://doi.org/10.1007/s00018-010-0391-x

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