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Different mosquito species host Wickerhamomyces anomalus (Pichia anomala): perspectives on vector-borne diseases symbiotic control

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An Erratum to this article was published on 28 May 2014

Abstract

The genetic manipulation of the microbial community associated with hematophagus insects is particularly relevant for public health applications. Within mosquito populations, this relationship has been overlooked until recently. New advances in molecular biotechnology propose the genetic manipulation of mosquito symbionts to prevent the transmission of pathogens to humans by interfering with the obligatory life cycle stages within the insect through the use of effector molecules. This approach, defined as ‘paratransgenesis’, has opened the way for the investigation and characterization of microbes residing in the mosquito body, particularly those localised within the gut. Some interesting bacteria have been identified as candidates for genetic modification, however, endosymbiotic yeasts remain largely unexplored with little information on the symbiotic relationships to date. Here we review the recent report of symbiotic relationship between Wickerhamomyces anomalus (Pichia anomala) and several mosquito vector species as promising methods to implement control of mosquito-borne diseases.

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Acknowledgments

I.R. was funded by “Compagnia di San Paolo” in the context of the Italian Malaria Network. E.C. and P.R. received a travel Grant from the COST Action FA0701. The research activity was supported by Firb-Ideas (Grant RBID082MLZ) and Prin 2007 (Grant 2007PK2HB7-002) both from the Italian Ministry of Education, University and Research (MIUR) to G.F.

We thank Chenoa De Freece for English revision of the manuscript.

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Authors and Affiliations

  1. Scuola di Bioscienze e Biotecnologie, Università degli Studi di Camerino, 62032, Camerino, Italy

    Irene Ricci, Michela Mosca, Matteo Valzano, Claudia Damiani, Patrizia Scuppa, Paolo Rossi, Alessia Cappelli, Ulisse Ulissi, Aida Capone, Fulvio Esposito & Guido Favia

  2. Dipartimento di Scienze e Tecnologie Alimentari e Microbiologiche, Università degli Studi di Milano, 20133, Milan, Italy

    Elena Crotti & Daniele Daffonchio

  3. Dipartimento di Valorizzazione e Protezione delle Risorse Agroforestali, Università degli Studi di Torino, 10095, Turin, Italy

    Alberto Alma

  4. Dipartimento di Biologia, Università degli Studi di Modena e Reggio Emilia, 41125, Modena, Italy

    Mauro Mandrioli

  5. Dipartimento di Biologia Animale, Università degli Studi di Pavia, 27100, Pavia, Italy

    Luciano Sacchi

  6. Dipartimento di Patologia Animale, Igiene e Sanità Pubblica Veterinaria, Università degli Studi di Milano, 20133, Milan, Italy

    Claudio Bandi

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  1. Irene Ricci
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Corresponding author

Correspondence to Guido Favia.

Additional information

We refer to ‘symbiotic relationship’ as de Bary (1879) defined it and used the term ‘endosymbiont’ to mean an internal associate of the insect including the gut.

An erratum to this article is available at http://dx.doi.org/10.1007/s10482-014-0199-z.

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Ricci, I., Mosca, M., Valzano, M. et al. Different mosquito species host Wickerhamomyces anomalus (Pichia anomala): perspectives on vector-borne diseases symbiotic control. Antonie van Leeuwenhoek 99, 43–50 (2011). https://doi.org/10.1007/s10482-010-9532-3

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