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Relationship of Medication Management Test-Revised (MMT-R) Performance to Neuropsychological Functioning and Antiretroviral Adherence in Adults with HIV

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Abstract

While performance-based tests of everyday functioning offer promise in facilitating diagnosis and classification of HIV-associated neurocognitive disorders (HAND), there remains a dearth of well-validated instruments. In the present study, clinical correlates of performance on one such measure (i.e., Medication Management Test—Revised; MMT-R) were examined in 448 HIV+ adults who were prescribed antiretroviral therapy. Significant bivariate relationships were found between MMT-R scores and demographics (e.g., education), hepatitis C co-infection, estimated premorbid IQ, neuropsychological functioning, and practical work abilities. MMT-R scores were not related to HIV disease severity, psychiatric factors, or self-reported adherence among participants with a broad range of current health status. However, lower MMT-R scores were strongly and uniquely associated with poorer adherence among participants with CD4 T cell counts <200. In multivariate analyses, MMT-R scores were predicted by practical work abilities, estimated premorbid functioning, attention/working memory, learning, and education. Findings provide overall mixed support for the construct validity of the MMT-R and are discussed in the context of their clinical and research implications for evaluation of HAND.

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Acknowledgments

This research was supported by NIH contract N01 MH2205 (CHARTER; PI: I. Grant). Participating sites include: Johns Hopkins University (J. McArthur); Mt. Sinai School of Medicine (S. Morgello & D. Simpson); University of California, San Diego (J.A. McCutchan); University of Texas Medical Branch, Galveston (B. Gelman); University of Washington, Seattle (A. C. Collier & C. Marra); Washington University, St. Louis (D. Clifford).

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Authors and Affiliations

  1. Children’s Diagnostic & Treatment Center, 1401 South Federal Highway, Fort Lauderdale, FL, 33316, USA

    Doyle E. Patton

  2. Department of Psychiatry, University of California, San Diego, USA

    Steven Paul Woods, Donald Franklin Jr., Robert K. Heaton, J. Allen McCutchan & Igor Grant

  3. Clinical Psychology, San Diego State University and University of California, San Diego, USA

    Jordan E. Cattie

  4. Harborview Medical Center and University of Washington, Seattle, WA, USA

    Ann C. Collier & Christina Marra

  5. Neuroscience Center, Washington University, St. Louis, MO, USA

    David Clifford

  6. Department of Pathology, University of Texas, Medical Branch, Galveston, TX, USA

    Benjamin Gelman

  7. Department of Neurology, Johns Hopkins University, Baltimore, MD, USA

    Justin McArthur

  8. Department of Pathology, Mount Sinai School of Medicine, New York, NY, USA

    Susan Morgello

  9. Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA

    David Simpson

  10. UCSD HIV Neurobehavioral Research Program, 220 Dickinson Street, Suite B, 8231, San Diego, CA, 92103, USA

    Steven Paul Woods

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  1. Doyle E. Patton
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  2. Steven Paul Woods
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  3. Donald Franklin Jr.
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  8. David Clifford
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  9. Benjamin Gelman
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  10. Justin McArthur
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  11. Susan Morgello
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  12. David Simpson
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  13. J. Allen McCutchan
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  14. Igor Grant
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Corresponding author

Correspondence to Steven Paul Woods.

Additional information

The study is conducted for the CHARTER Group.

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Patton, D.E., Woods, S.P., Franklin, D. et al. Relationship of Medication Management Test-Revised (MMT-R) Performance to Neuropsychological Functioning and Antiretroviral Adherence in Adults with HIV. AIDS Behav 16, 2286–2296 (2012). https://doi.org/10.1007/s10461-012-0237-7

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  • DOI: https://doi.org/10.1007/s10461-012-0237-7

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