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Positive and negative feedback mechanisms controlling tip/stalk cell identity during sprouting angiogenesis

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Abstract

Vascular endothelial growth factor-A (VEGF-A/VEGF) interaction with VEGF receptor 2 (VEGFR2) is key for sprouting angiogenesis in health and disease. VEGF/VEGFR2 signaling promotes endothelial proliferation and migration, as well as the hierarchical organization into leader (tip) and follower (stalk) cells via a dynamic interplay with Notch. Recent studies reveal novel molecular mechanisms to fine-tune VEGF/Notch signaling and tip/stalk cell function during sprouting angiogenesis.

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Abbreviations

aPKC:

Atypical PKC

DAG:

Diacylglycerol

Dll4:

Delta-like ligand 4

ER:

Endoplasmic reticulum

ERK:

Extracellular signal-regulated kinase

FOXO1:

Forkhead box protein O1

IP3:

Inositoltrisphosphate

Mst1:

Mammalian sterile 20-like kinase 1

ROS:

Reactive oxygen species

PI3-K:

Phosphoinositide 3-kinase

PKC:

Protein kinase C

TMEM33:

Transmembrane protein 33

VEGF:

Vascular endothelial growth factor

VEGFR2:

VEGF receptor 2

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  1. Sanquin Research and Landsteiner Laboratory, Plesmanlaan 125, 1066 CX, Amsterdam, The Netherlands

    Coert Margadant

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  1. Coert Margadant
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Correspondence to Coert Margadant.

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Margadant, C. Positive and negative feedback mechanisms controlling tip/stalk cell identity during sprouting angiogenesis. Angiogenesis 23, 75–77 (2020). https://doi.org/10.1007/s10456-020-09706-0

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  • DOI: https://doi.org/10.1007/s10456-020-09706-0

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