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History and conceptual developments in vascular biology and angiogenesis research: a personal view

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Abstract

Vascular biology is an important scientific domain that has gradually penetrated many medical and scientific fields. Scientists are most often focused on present problems in their daily scientific work and lack awareness regarding the evolution of their domain throughout history and of how philosophical issues are related to their research field. In this article, I provide a personal view with an attempt to conceptualize vascular development research that articulates lessons taken from history, philosophy, biology and medicine. I discuss selected aspects related to the history and the philosophy of sciences that can be extracted from the study of vascular development and how conceptual progress in this research field has been made. I will analyze paradigm shifts, cross-fertilization of different fields, technological advances and its impact on angiogenesis and discuss issues related to evolutionary biology, proximity of different molecular systems and scientific methodologies. Finally, I discuss briefly my views where the field is heading in the future.

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Acknowledgements

Elements discussed in this article are based on the book « Une brève histoire du vaisseau sanguin et lymphatique » published by the author in 2016 (permission granted by EDP Science). An English version of the book will be edited by Springer Verlag and will be available in fall 2017. For a complete history of vascular biology from an angiogenesis perspective, the reader may refer to these books. This work was supported by the National Institute of Health and Medical Research (INSERM) and the Ligue Nationale du Cancer (Comités départementaux, Charente Maritime, etc.). The author would like to thank Clotilde Billottet, Klaus Petry and Lindsay Cooley (LAMC-INSERM U1029) for critical reading of the manuscript.

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  1. INSERM U1029 (Angiogenesis and Tumor Microenvironment Laboratory), Allée Geoffroy St Hilaire, 33560, Pessac, France

    Andreas Bikfalvi

  2. Université Bordeaux (Angiogenesis and Tumor Microenvironment Laboratory), Allée Geoffroy St Hilaire, 33560, Pessac, France

    Andreas Bikfalvi

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  1. Andreas Bikfalvi
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Correspondence to Andreas Bikfalvi.

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Bikfalvi, A. History and conceptual developments in vascular biology and angiogenesis research: a personal view. Angiogenesis 20, 463–478 (2017). https://doi.org/10.1007/s10456-017-9569-2

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  • DOI: https://doi.org/10.1007/s10456-017-9569-2

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