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Interactions between VEGFR and Notch signaling pathways in endothelial and neural cells

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Abstract

Notch cell interaction mechanism governs cell fate decisions in many different cell contexts throughout the lifetime of all Metazoan species. It links the fate of one cell to that of its neighbors through cell-to-cell contacts, and binding of Notch receptors expressed on one cell to their membrane bound ligands on an adjacent cell. Environmental cues, such as growth factors and extracellular matrix molecules, superimpose a dynamic regulation on this canonical Notch signaling pathway. In this review, we will focus on Notch signaling in the vertebrate vascular and nervous systems and examine its role in angiogenesis, neurogenesis, and neurovascular interactions. We will also highlight the molecular relationships of the Notch pathway with vascular endothelial growth factors (VEGFs) and their high-affinity tyrosine kinase VEGF receptors, key regulators of both angiogenesis and neurogenesis.

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Acknowledgments

This work was supported by Yale University School of Medicine (JLT, AE), NIH RO1HL111504-02 (AE, JLT, JH, KB), ANR blanc Neuroscience 2010 (JLT), Academy of Finland (KI, HN). We are indebted to Abdelkrim Mannioui and Hatem Hmidan for technical assistance.

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Authors and Affiliations

  1. Department of Neurology, Yale University School of Medicine, New Haven, CT, 06510-3221, USA

    Jean-Leon Thomas

  2. Department of Cardiology, Yale University School of Medicine, New Haven, CT, 06510-3221, USA

    Kasey Baker, Jinah Han & Anne C. Eichmann

  3. Université Pierre and Marie Curie–Paris 6, CRICM, Groupe Hospitalier Pitié-Salpètrière, 75013, Paris, France

    Jean-Leon Thomas & Charles Calvo

  4. INSERM, UMRS 975, Groupe Hospitalier Pitié-Salpètrière, 75013, Paris, France

    Jean-Leon Thomas & Charles Calvo

  5. APHP, Groupe Hospitalier Pitié-Salpètrière, 75013, Paris, France

    Jean-Leon Thomas & Charles Calvo

  6. Wihuri Institute and Molecular Molecular/Cancer Biology Laboratory, Biomedicum Helsinki and Department of Pathology Haartman Institute, University of Helsinki, Helsinki, Finland

    Harri Nurmi & Kari Alitalo

  7. CNRS/UMR, Center for Interdisciplinary Research in Biology, 7241-INSERM U1050, Collège de France, 75005, Paris, France

    Anne C. Eichmann

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  1. Jean-Leon Thomas
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Correspondence to Jean-Leon Thomas.

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Thomas, JL., Baker, K., Han, J. et al. Interactions between VEGFR and Notch signaling pathways in endothelial and neural cells. Cell. Mol. Life Sci. 70, 1779–1792 (2013). https://doi.org/10.1007/s00018-013-1312-6

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  • DOI: https://doi.org/10.1007/s00018-013-1312-6

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