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Thymosin β4 and angiogenesis: modes of action and therapeutic potential

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Abstract

Here we review the mechanisms by which Thymosin β4 (Tβ4) regulates angiogenesis, its role in processes, such as wound healing and tumour progression and we discuss in more detail the role of Tβ4 in the cardiovascular system and significant recent findings implicating Tβ4 as a potential therapeutic agent for ischaemic heart disease.

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Acknowledgements

We thank all of the investigators who allowed us to reproduce figures and provided originals, as referenced. Our work is supported by the British Heart Foundation and the Medical Research Council.

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  1. Molecular Medicine Unit, UCL-Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK

    Nicola Smart, Alex Rossdeutsch & Paul R. Riley

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Smart, N., Rossdeutsch, A. & Riley, P.R. Thymosin β4 and angiogenesis: modes of action and therapeutic potential. Angiogenesis 10, 229–241 (2007). https://doi.org/10.1007/s10456-007-9077-x

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