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Nanoparticle-Hydrogel: A Hybrid Biomaterial System for Localized Drug Delivery

  • Emerging Trends in Biomaterials Research
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Abstract

Nanoparticles have offered a unique set of properties for drug delivery including high drug loading capacity, combinatorial delivery, controlled and sustained drug release, prolonged stability and lifetime, and targeted delivery. To further enhance therapeutic index, especially for localized application, nanoparticles have been increasingly combined with hydrogels to form a hybrid biomaterial system for controlled drug delivery. Herein, we review recent progresses in engineering such nanoparticle-hydrogel hybrid system (namely ‘NP-gel’) with a particular focus on its application for localized drug delivery. Specifically, we highlight four research areas where NP-gel has shown great promises, including (1) passively controlled drug release, (2) stimuli-responsive drug delivery, (3) site-specific drug delivery, and (4) detoxification. Overall, integrating therapeutic nanoparticles with hydrogel technologies creates a unique and robust hybrid biomaterial system that enables effective localized drug delivery.

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Acknowledgment

This work is supported by the National Science Foundation Grant DMR-1505699 and the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health under Award Number R01DK095168.

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  1. Department of Nanoengineering and Moores Cancer Center, University of California, San Diego, La Jolla, CA, 92093, USA

    Weiwei Gao, Yue Zhang, Qiangzhe Zhang & Liangfang Zhang

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  1. Weiwei Gao
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  2. Yue Zhang
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Correspondence to Liangfang Zhang.

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Associate Editor Akhilesh K Gaharwar oversaw the review of this article.

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Gao, W., Zhang, Y., Zhang, Q. et al. Nanoparticle-Hydrogel: A Hybrid Biomaterial System for Localized Drug Delivery. Ann Biomed Eng 44, 2049–2061 (2016). https://doi.org/10.1007/s10439-016-1583-9

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