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A Novel Carotid Covered Stent Design: In Vitro Evaluation of Performance and Influence on the Blood Flow Regime at the Carotid Artery Bifurcation

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Abstract

In the present study, a novel carotid covered stent design has been developed. Prototypes of different geometrical design parameters have been fabricated and their performance has been evaluated in vitro under physiological pulsatile flow condition, utilizing flow visualization (dye injection), and particle image velocimetry techniques. These evaluations include the assessment of emboli prevention capability, side-branch flow preservation, and influence on the branch flow pattern and velocity field. The novel covered stents demonstrated significantly higher emboli prevention capability than the corresponding bare metal stent, while preserving more than 83% of the original flow of the external carotid artery (ECA). Flow in the ECA through these covered stents was uniform without evidence of undesirable flow recirculation and reversed flow that might predispose the vessel wall to post-stenting intimal thickening and atherosclerotic plaque formation. This study demonstrated the potential of these novel covered stent designs for the treatment of carotid atherosclerotic stenosis. However, further computational and in vivo investigations of hemodynamics, biological effects, and mechanical performance of this covered stent design is warranted.

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Acknowledgments

This project is financially supported by Biomedical Engineering Programme (BEP) of the Agency for Science, Technology and Research (A*STAR), under grant BEP-1021480004.

Conflict of interest

The authors affirm that there are no financial and personal relationships or involvement with any commercial organization that could inappropriately influence or bias the present manuscript.

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Authors and Affiliations

  1. Department of Bioengineering, National University of Singapore, 9 Engineering Drive 1, Block EA #03-12, Singapore, 117576, Singapore

    Foad Kabinejadian & Hwa Liang Leo

  2. Institute of High Performance Computing (IHPC), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore

    Fangsen Cui

  3. Department of Surgery, National University of Singapore, Singapore, Singapore

    Zhe Zhang

  4. Department of Cardiac, Thoracic & Vascular Surgery, National University Health System, Singapore, Singapore

    Pei Ho

Authors
  1. Foad Kabinejadian
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  2. Fangsen Cui
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  3. Zhe Zhang
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  4. Pei Ho
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  5. Hwa Liang Leo
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Corresponding author

Correspondence to Hwa Liang Leo.

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Associate Editor Peter E. McHugh oversaw the review of this article.

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Kabinejadian, F., Cui, F., Zhang, Z. et al. A Novel Carotid Covered Stent Design: In Vitro Evaluation of Performance and Influence on the Blood Flow Regime at the Carotid Artery Bifurcation. Ann Biomed Eng 41, 1990–2002 (2013). https://doi.org/10.1007/s10439-013-0863-x

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  • DOI: https://doi.org/10.1007/s10439-013-0863-x

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