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Tunable Nanostructures as Photothermal Theranostic Agents

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An Erratum to this article was published on 10 March 2012

Abstract

The theranostic potential of several nanostructures has been discussed in the context of photothermal therapies and imaging. In the last several decades, the burden of cancer has grown rapidly, making the need for new theranostic approaches vital. Lasers have emerged as promising tools in cancer treatment, especially with the advent of photothermal therapies wherein light absorbing dyes or plasmonic gold nanoparticles are used to generate heat and achieve tumor damage. Recently, photoabsorbing nanostructures have materialized that can be employed in conjunction with lasers in the near-infrared region in order to enhance both imaging and photothermal effects. The incorporation of tunable nanostructures has resulted in improved specificity in cancer treatment. Silica-cored gold nanoshells and gold nanorods currently serve as the chief plasmonic structures for photothermal therapy. Although gold nanorods and silica-cored gold nanoshells have shown promise as therapeutic agents, over the past few years new nanostructures have emerged that offer comparable and even superior theranostic properties. In the present review, several theranostic agents and their impact on the development of more effective photothermal therapies for the treatment of cancer are discussed. These agents include hollow gold nanoshells, gold gold-sulfide nanoparticles, gold nanocages, carbon and titanium nanotubes, photothermal-based nanobubbles, polymeric nanoparticles and copper-based nanocrystals.

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Acknowledgments

We acknowledge financial support from the National Science Foundation, Dod CDMRP era of hope scholar award, and the NIH grand opportunities RC2 award.

Conflicts of interest

No benefits in any form have been or will be received from a commercial party related directly or indirectly to the subject of this manuscript.

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Authors and Affiliations

  1. Department of Electrical and Computer Engineering, Rice University, 6100 Main Street, Houston, TX, 77005, USA

    Joseph K. Young & Rebekah A. Drezek

  2. Department of Bioengineering, Rice University, 6100 Main Street, Houston, TX, 77005, USA

    Elizabeth R. Figueroa & Rebekah A. Drezek

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  1. Joseph K. Young
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  2. Elizabeth R. Figueroa
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Correspondence to Rebekah A. Drezek.

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Associate Editor Bahman Anvari oversaw the review of this article.

J. K. Young and E. R. Figueroa have contributed equally to this work.

An erratum to this article can be found at http://dx.doi.org/10.1007/s10439-012-0535-2.

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Young, J.K., Figueroa, E.R. & Drezek, R.A. Tunable Nanostructures as Photothermal Theranostic Agents. Ann Biomed Eng 40, 438–459 (2012). https://doi.org/10.1007/s10439-011-0472-5

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