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Hemoglobin Glycation Rate Constant in Non-diabetic Individuals

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Abstract

The objectives were as follows: (1) estimating mean value of the overall hemoglobin glycation rate constant (k); (2) analyzing inter-individual variability of k; (3) verifying ability of the hemoglobin A1c (HbA1c) formation model to predict changes of HbA1c during red blood cells cultivation in vitro and to reproduce the clinical data. The mean k estimated in a group of 10 non-diabetic subjects was equal to 1.257 ± 0.114 × 10−9 L mmol−1 s−1. The mean k was not affected by a way of estimation of glycemia. The mean k differed less than 20% from values reported earlier and it was almost identical to the mean values calculated on basis of the selected published data. Analysis of variability of k suggests that inter-individual heterogeneity of HbA1c formation is limited or rare. The HbA1c mathematical model was able to predict changes of HbA1c in vitro resulting from different glucose levels and to reproduce a linear relationship of HbA1c and average glucose obtained in the A1C-Derived Average Glucose Study. This study demonstrates that the glycation model with the same k value might be used in majority of individuals as a tool supporting interpretation of HbA1c in different clinical situations.

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Acknowledgments

This work was supported by a research grant from the National Centre for Science (Grant no. N N518 289340).

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Authors and Affiliations

  1. Department of Biomedical Systems and Technologies, Nałęcz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, 4 Trojdena Street, 02-109, Warsaw, Poland

    Piotr Ładyżyński, Jan M. Wójcicki, Stanisława Sabalińska, Jerzy Kawiak & Piotr Foltyński

  2. Department and Clinic of Gastroenterology and Metabolic Diseases, Medical University of Warsaw, 1A Banacha Str., 02-097, Warsaw, Poland

    Marianna I. Bąk, Janusz Krzymień & Waldemar Karnafel

Authors
  1. Piotr Ładyżyński
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  2. Jan M. Wójcicki
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  3. Marianna I. Bąk
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  4. Stanisława Sabalińska
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  5. Jerzy Kawiak
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  6. Piotr Foltyński
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  7. Janusz Krzymień
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  8. Waldemar Karnafel
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Correspondence to Piotr Ładyżyński.

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Associate Editor Gerald Saidel oversaw the review of this article.

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Ładyżyński, P., Wójcicki, J.M., Bąk, M.I. et al. Hemoglobin Glycation Rate Constant in Non-diabetic Individuals. Ann Biomed Eng 39, 2721–2734 (2011). https://doi.org/10.1007/s10439-011-0366-6

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  • DOI: https://doi.org/10.1007/s10439-011-0366-6

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