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Surface Modifications of Magnesium Alloys for Biomedical Applications

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Abstract

In recent years, research on magnesium (Mg) alloys had increased significantly for hard tissue replacement and stent application due to their outstanding advantages. Firstly, Mg alloys have mechanical properties similar to bone which avoid stress shielding. Secondly, they are biocompatible essential to the human metabolism as a factor for many enzymes. In addition, main degradation product Mg is an essential trace element for human enzymes. The most important reason is they are perfectly biodegradable in the body fluid. However, extremely high degradation rate, resulting in too rapid loss of mechanical strength in chloride containing environments limits their applications. Engineered artificial biomaterials with appropriate mechanical properties, surface chemistry, and surface topography are in a great demand. As the interaction between the cells and tissues with biomaterials at the tissue–implant interface is a surface phenomenon; surface properties play a major role in determining both the biological response to implants and the material response to the physiological condition. Therefore, the ability to modify the surface properties while preserve the bulk properties is important, and surface modification to form a hard, biocompatible and corrosion resistant modified layer have always been an interesting topic in biomaterials field. In this article, attempts are made to give an overview of the current research and development status of surface modification technologies of Mg alloys for biomedical materials research. Further, the advantages/disadvantages of the different methods and with regard to the most promising method for Mg alloys are discussed. Finally, the scientific challenges are proposed based on own research and the work of other scientists.

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Acknowledgments

This work was partially supported by a grant (code #: 2009K000435) from Center for Nanostructured Materials Technology under 21st Century Frontier R&D Program of the Ministry of Education, Science and Technology, Korea.

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  1. Advanced Materials Laboratory, Department of Materials Science and Engineering, Tsinghua University, Beijing, 100084, China

    Jingxin Yang & Fuzhai Cui

  2. Atomic-Scale Surface Science Research Center, Yonsei University, Seoul, 120-749, South Korea

    In Seop. Lee

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Yang, J., Cui, F. & Lee, I.S. Surface Modifications of Magnesium Alloys for Biomedical Applications. Ann Biomed Eng 39, 1857–1871 (2011). https://doi.org/10.1007/s10439-011-0300-y

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