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Improving Hollow Fiber Dialyzer Efficiency with a Recirculating Dialysate System II: Comparison Against Two-Chamber Dialysis Systems

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Abstract

The theoretical basis of the nonregenerated recirculating dialysate system (RDS) was derived in Part I of this work [M. Prado, L. M. Roa, A. Palma, and J. A. Milán, Ann. Biomed. Eng. (2005)]. This system pursues the maximization of the clearance of hollow fiber dialyzers whose performance is controlled by diffusion, as occurred in standard hemodialysis. In this second part we perform a comparison by digital simulation of the RDS against three well-known two-chamber dialysis systems. As a major outcome, the efficiency of the RDS increased by a factor of five–eight with respect to the efficiency of a single dialyzer operating with a number of transfer units equal to 0.1, that is when the diffusive mass-transfer of the dialyzer is exhausted. Present low-flux dialyzers do not take advantage of the full potential of this technique, but the functional domain where high-flux and high-area dialyzers operate could be more suitable to exploit this technique. We conclude that RDS can be a competitive efficient technique for optimizing the dialysis efficiency.

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Authors and Affiliations

  1. Biomedical Engineering Group, University of Seville, Seville, Spain

    Manuel Prado, Laura M. Roa, Alfonso Palma & José A. Milán

  2. Nephrology Service, University Hospital, Virgen Macarena, Spain

    Alfonso Palma & José A. Milán

  3. Grupo de Ingeniería Biomédica, Escuela Superior de Ingeniería, Universidad de Sevilla, Camino de los descubrimientos s/n, Sevilla, Spain, 41092

    Manuel Prado

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  1. Manuel Prado
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  2. Laura M. Roa
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  3. Alfonso Palma
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  4. José A. Milán
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Correspondence to Manuel Prado.

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Prado, M., Roa, L.M., Palma, A. et al. Improving Hollow Fiber Dialyzer Efficiency with a Recirculating Dialysate System II: Comparison Against Two-Chamber Dialysis Systems. Ann Biomed Eng 33, 1595–1606 (2005). https://doi.org/10.1007/s10439-005-6884-3

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  • DOI: https://doi.org/10.1007/s10439-005-6884-3

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