Skip to main content
SpringerLink
Log in

Role of elements and physiologically active compounds in the regulation of synthesis and accumulation of indole alkaloids in Catharanthus roseus L.

  • Published:
Applied Biochemistry and Microbiology Aims and scope Submit manuscript

Abstract

Effects of various elements (Co, Ni, Zn, W, Mn, Cr, B, Mo, Fe, and V), natural and synthetic auxins, cytokinins, and gibberellin on biosynthesis and accumulation of indole alkaloids was studied at increasing concentrations in the model system of Madagascar periwinkle seedlings (Catharanthus roseus L.). The main types of concentration dependences for the effect of physiologically active compounds under study were evaluated. A possible mechanism of the influence of Zn and auxin on this process was partly clarified. The compounds were shown to modulate various stages in the biosynthesis of monomeric indole alkaloids (catharanthine and vindoline).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

REFERENCES

  1. Heijden, R., van Jacobs, D.I., Snoeijer, W., Hallard, D., and Verpoorte, R., Curr. Med. Chem., 2004, vol. 11, no.5, pp. 607–628.

    Article  PubMed  Google Scholar 

  2. Svoboda, G.H. and Blake, D.A., in The Catharanthus Alkaloids: Botany, Chemistry, Pharmacology and Clinical Uses, Taylor, W.I. and Farnsworth, N.R., Eds., New York: Marcel Dekker, 1975, pp. 45–83.

    Google Scholar 

  3. Buzuk, G.N., Lovkova, M.Ya., and Grinkevich, N.I., Prikl. Biokhim. Mikrobiol., 1980, vol. 16, no.3, pp. 432–438.

    CAS  Google Scholar 

  4. Lovkova, M.Ya., Buzuk, G.N., Kliment’eva, N.I., and Grinkevich, N.I., Prikl. Biokhim. Mikrobiol., 1983, vol. 19, no.4, pp. 560–563.

    CAS  PubMed  Google Scholar 

  5. Jensen, R.A., Physiol. Plant., 1986, vol. 66, no.1, pp. 164–168.

    CAS  Google Scholar 

  6. Rubin, J.L. and Jensen, R.A., Plant Physiol., 1985, vol. 79, no.3, pp. 711–718.

    CAS  Google Scholar 

  7. Sajo, R. and Kosuge, T., Phytochemistry, 1978, vol. 17, no.2, pp. 223–225.

    Article  Google Scholar 

  8. Dobrolyubskii, O.K. and Evstratova, T.M., Fiziol. Biokh. Kul’t. Rast., 1978, vol. 10, no.1, pp. 95–99.

    CAS  Google Scholar 

  9. Kretovich, V.L., Usvoenie i metabolizm azota u rastenii (Assimilation and Metabolism of Nitrogen in Plants), Moscow: Nauka, 1987.

    Google Scholar 

  10. Floss, H.G., Recent Adv. Phytochem., 1986.

  11. Miflin, B.J. and Lea, P.J., Annu. Rev. Plant Physiol., 1977, vol. 28, pp. 299–329.

    Article  CAS  Google Scholar 

  12. Miflin, B.J. and Lea, P.J., Encycl. Plant Physiol. New Ser., 1982, vol. 14A, no.1, pp. 5–64.

    CAS  Google Scholar 

  13. Shchitaeva, V.A., Izv. AN Tadzh. SSR, Ser. Biol. Nauki, 1984, no. 4, pp. 8–13.

  14. Kutachek, M., Mashev, N.P., Oplishtilova, K., and Bulgakov, R., Stimulyatsiya rastenii (Stimulation of Plants), Sofia: Nauka, 1969.

    Google Scholar 

  15. Mashev, N., Nauchni trudove (Sofia), Sofia, 1968, vol. 17, no.1, pp. 243–248.

    Google Scholar 

  16. Mashev, N., Fiziologiya rasteniyata (Sofia), 1974, vol. 1, no.1, pp. 47–54.

    CAS  Google Scholar 

  17. Mashev, N., Fiziologiya rasteniyata (Sofia) 1974, vol. 1, no.2, pp. 321–332.

    Google Scholar 

  18. Masev, N., Popov, N.N., and Masheva, L.G., Plant Growth Regulators. Proc. III Int. Symp. Plant Growth Substances, Sofia, 1983, pp. 53–56.

  19. Popov, N.N. and Mashev, N.P., Fiziologiya rasteniyata (Sofia), 1980, vol. 7, no.1, pp. 90–95.

    Google Scholar 

  20. Horak, V., Ircka, I., and Stefl, M., Biol. Plant., 1976, vol. 18, no.5, pp. 393–396.

    CAS  Google Scholar 

  21. Klein, R.M., Caputo, E.M., and Witterholt, B.A., Am. J. Bot., 1962, vol. 49, no.4, pp. 323–327.

    CAS  Google Scholar 

  22. Tsui, C. and Wu, C.M., Sci. Record., 1960, vol. 4, no.1, pp. 54–57.

    CAS  Google Scholar 

  23. Chen, J. and Boll, W.G., Can. J. Bot., 1968, vol. 46, no.8, pp. 1031–1033.

    CAS  Google Scholar 

  24. Rao, K.K. and Gupta, A.R., Curr. Sci., 1974, vol. 43, no.13, p. 415.

    CAS  Google Scholar 

  25. Vallee, B.L., Biological Aspects of Inorganic Chemistry, New York: Academic, 1977, pp. 37–70.

    Google Scholar 

  26. Vallee, B.L. and Falchuk, K., Proc. Roy. Soc., London: Ser. B, 1981, vol. 294, no.1074, pp. 185–197.

    Google Scholar 

  27. Williams, R.J.P., Polyhedron, 1987, vol. 6, no.1, pp. 61–69.

    Article  CAS  Google Scholar 

  28. Kitagishi, K., Obata, H., and Kondo, T., Soil Sci. Plant Nutr., 1987, vol. 33, no.3, pp. 423–429.

    Google Scholar 

  29. Obata, H. and Umebayashi, M., Soil. Sci. Plant Nutr., 1988, vol. 34, no.3, pp. 351–358.

    CAS  Google Scholar 

  30. Porokhnevich, N.V. and Ivanov, N.P., Fiziol. Rast. (Moscow), 1975, vol. 22, no.2, pp. 306–311.

    Google Scholar 

  31. DeLuca, V. and Cutler, A.J., Plant Physiol., 1987, vol. 85, no.4, pp. 1099–1102.

    CAS  Google Scholar 

  32. Vlasyuk, P.A., Zhidkov, V.A., Ivchenko, V.I., Klimovitskaya, E.M., Okhrimenko, M.F., Rudakova, E.V., and Sidorzhina, T.N., in Biologicheskaya rol’ mikroelementov (Biological Role of Microelements), Moscow: Nauka, 1983, pp. 97–105.

    Google Scholar 

  33. Rudakova, E.V. and Karakis, K.D., in Mikroelementy v obmene veshchestv rastenii (Microelements in Plant Metabolism), Kiev: Naukova dumka, 1976, pp. 126–176.

    Google Scholar 

  34. Buzuk, G.N., Lovkova, M.Ya., and Sabirova, N.S., Rastit. Resur., 1989, vol. 25, no.2, pp. 155–160.

    CAS  Google Scholar 

  35. Markiewicz, L., Bull. Acad. Polon. Sci. Ser. Biol, 1965, vol. 13, no.8, pp. 475–478.

    CAS  Google Scholar 

  36. Masoud, A.N., Sciuchetti, L.A., Farnsworth, N.R., Blomster, R.N., and Meer, W.A., J. Pharm. Sci., 1968, vol. 57, no.4, pp. 589–593.

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow, 119071, Russia

    M. Ya. Lovkova

  2. Vitebsk Medical University, Vitebsk, 210026, Belarus

    G. N. Buzuk & L. N. Buzuk

  3. Tsitsin Main Botanical Garden, Russian Academy of Sciences, Moscow, 127276, Russia

    S. M. Sokolova

Authors
  1. M. Ya. Lovkova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. N. Buzuk
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. M. Sokolova
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. L. N. Buzuk
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

__________

Translated from Prikladnaya Biokhimiya i Mikrobiologiya, Vol. 41, No. 3, 2005, pp. 340–346.

Original Russian Text Copyright © 2005 by Lovkova, G. Buzuk, Sokolova, L. Buzuk.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lovkova, M.Y., Buzuk, G.N., Sokolova, S.M. et al. Role of elements and physiologically active compounds in the regulation of synthesis and accumulation of indole alkaloids in Catharanthus roseus L.. Appl Biochem Microbiol 41, 299–305 (2005). https://doi.org/10.1007/s10438-005-0050-4

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10438-005-0050-4

Keywords

Search

Navigation