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Effects of internal limiting membrane peeling on anatomical and functional outcomes in macula-off rhegmatogenous retinal detachment complicated by proliferative vitreoretinopathy: Japan-Retinal Detachment Registry

  • Clinical Investigation
  • Published:
Japanese Journal of Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To investigate the effects of internal limiting membrane (ILM) peeling on retinal attachment after a single surgery, and on postoperative visual acuity (VA) at 6 months, in eyes with macula-off rhegmatogenous retinal detachment (RRD) complicated by proliferative vitreoretinopathy (PVR).

Study design

Nationwide, multicenter retrospective cohort study.

Methods

The Japan-RD Registry database was used for analysis of patients who had undergone vitrectomy for macula-off RRD complicated by PVR. Multivariate analysis was performed to detect prognostic factors for retinal attachment after a single surgery and for VA at 6 months postoperatively. Retinal attachment after a single surgery or VA at 6 months postoperatively was the objective variable; ILM peeling, preoperative VA, PVR grade, age, and intraocular pressure were explanatory variables.

Results

Eighty-nine eyes met the inclusion criteria; ILM peeling was performed in 25 eyes (28%). Preoperative VA was significantly associated with retinal attachment, but ILM peeling did not (odds ratios = 2.1 and 1.3, respectively; p = 0.009 and 0.67, respectively). Poor preoperative VA and younger patient age were significantly associated with poor postoperative VA, but ILM peeling was not (β-values = 0.37, −0.008, and 0.15, respectively; p < 0.001, p = 0.02, and p = 0.15, respectively.

Conclusions

Preoperative VA was a risk factor associated with retinal attachment. Preoperative VA and patient age were risk factors associated with postoperative poor VA. In eyes with macula-off RRD complicated by PVR, ILM peeling did not have a clear beneficial effect on anatomical and functional outcomes, suggesting that it may be unnecessary for eyes with this condition.

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Acknowledgments

This study did not receive financial or material support from the Japanese Retina and Vitreous Society. We thank Ryan Chastain-Gross, Ph.D., from Edanz (https://jp.edanz.com/ac) for editing a draft of this manuscript.

Study Group Investigators: J-RD Registry Project Committee collaborators and their affiliations: Chair of the J-RD Registry project committee: Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, 467-8601, Japan. Yuichiro Ogura, ogura.yuichiro@me.com. 1. Chiba University Graduate School of Medicine: Shuichi Yamamoto, Takayuki Baba, Eiju Sato, Masayasu Kitahashi, Tomoaki Tatsumi, Gen Miura, Tomohiro Nizawa. 2. Kagoshima University Graduate School of Medical and Dental Sciences: Taiji Sakamoto, Keita Yamakiri, Toshifumi Yamashita, Hiroki Otsuka, Seiji Sameshima, Narimasa Yoshinaga, Shozo Sonoda. 3. Kyorin University School of Medicine: Akito Hirakata, Takashi Koto, Makoto Inoue, Kazunari Hirota, Yuji Itoh, Tadashi Orihara, Yoshinobu Emoto, Masahiko Sano, Hiroyuki Takahashi, Ryo Tokizawa, 4. Yamagata University School of Medicine: Hidetoshi Yamashita, Koichi Nishitsuka, Yutaka Kaneko, Katsuhiro Nishi. 5. Asahikawa Medical University Hospital: Akitoshi Yoshida, Shinji Ono, Hiroyuki Hirokawa, Kenji Sogawa, Tsuneaki Omae, Akihiro Ishibazawa. 6. Gunma University: Shoji Kishi, Hideo Akiyama, Hidetaka Matsumoto, Ryo Mukai, Masahiro Morimoto. 7. Hirosaki University Graduate School of Medicine: Mitsuru Nakazawa, Yukihiko Suzuki, Takashi Kudo, Kobu Adachi. 8. Hokkaido University: Susumu Ishida, Kousuke Noda, Satoru Kase, Shohei Mori, Ryo Ando, Michiyuki Saito, Tomohiro Suzuki. 9. Kansai Medical University Hospital: Kanji Takahashi, Yoshimi Nagai, Tadashi Nakauchi, Haruhiko Yamada. 10. Kindai University Sakai Hospital: Shunji Kusaka, Daishi Tsujioka. 11. Kyoto University Graduate School of Medicine: Akitaka Tsujikawa, Kiyoshi Suzuma. 12. Kyushu University Hospital: Tatsuro Ishibashi, Koh-Hei Sonoda, Yasuhiro Ikeda, Riichiro Kohno, Keijiro Ishikawa. 13. Mie University School of Medicine: Mineo Kondo, Maki Kozawa. 14. Nagasaki University: Takashi Kitaoka, Eiko Tsuiki. 15. Nagoya City University: Yuichiro Ogura, Munenori Yoshida, Hiroshi Morita, Aki Kato, Yoshio Hirano, Kazuhiko Sugitani. 16. Nagoya University Graduate School of Medicine: Hiroko Terasaki, Takeshi Iwase, Yasuki Ito, Shinji Ueno, Hiroki Kaneko, Norie Nonobe, Taro Kominami. 17. National Center for Child Health and Development: Noriyuki Azuma, Tadashi Yokoi. 18. Nihon University School of Medicine: Hiroyuki Shimada, Hiroyuki Nakashizuka, Takayuki Hattori, Ari Shinojima, Yorihisa Kitagawa. 19. Okayama University Graduate School of Medicine: Fumio Shiraga, Yuki Morizane, Shuhei Kimura. 20. Osaka Medical College: Tsunehiko Ikeda, Teruyo Kida, Takaki Sato, Masanori Fukumoto. 21. Osaka Rosai Hospital Clinical Research Center for Optical Sensory Organ Disability: Kazuyuki Emi, Hiroshi Nakashima. 22. Shiga University of Medical Science: Masahito Ohji, Masashi Kakinoki, Osamu Sawada. 23. Takeuchi Eye Clinic: Shinobu Takeuchi, Sumiyoshi Tanaka. 24. Tokyo Women's Medical University School of Medicine: Tomohiro Iida, Hideki Koizumi, Ichiro Maruko, Taiji Hasegawa, Akiko Kogure. 25. University of Yamanashi: Hiroyuki Iijima, Tomohiro Oshiro, Yasushi Tateno, Wataru Kikushima, Atsushi Sugiyama, Seigo Yoneyama. 26. Yokohama City University Medical Center: Kazuaki Kadonosono, Shimpei Sato, Shin Yamane

Author information

Authors and Affiliations

  1. Department of Ophthalmology, Shiga University of Medical Science, Seta Tsukinowacho, Otsu, Shiga, 520-2192, Japan

    Shumpei Obata, Osamu Sawada, Masashi Kakinoki, Riko Matsumoto, Yoshitsugu Saishin & Masahito Ohji

  2. Japan-Retinal Detachment Registry Group, Osaka, Japan

    Osamu Sawada, Masashi Kakinoki & Masahito Ohji

Authors
  1. Shumpei Obata
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  2. Osamu Sawada
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  3. Masashi Kakinoki
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  4. Riko Matsumoto
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  5. Yoshitsugu Saishin
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  6. Masahito Ohji
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Consortia

the Japan-Retinal Detachment Registry Group

  • Shuichi Yamamoto
  • , Takayuki Baba
  • , Eiju Sato
  • , Masayasu Kitahashi
  • , Tomoaki Tatsumi
  • , Gen Miura
  • , Tomohiro Nizawa
  • , Taiji Sakamoto
  • , Keita Yamakiri
  • , Toshifumi Yamashita
  • , Hiroki Otsuka
  • , Seiji Sameshima
  • , Narimasa Yoshinaga
  • , Shozo Sonoda
  • , Akito Hirakata
  • , Takashi Koto
  • , Makoto Inoue
  • , Kazunari Hirota
  • , Yuji Itoh
  • , Tadashi Orihara
  • , Yoshinobu Emoto
  • , Masahiko Sano
  • , Hiroyuki Takahashi
  • , Ryo Tokizawa
  • , Hidetoshi Yamashita
  • , Koichi Nishitsuka
  • , Yutaka Kaneko
  • , Katsuhiro Nishi
  • , Akitoshi Yoshida
  • , Shinji Ono
  • , Hiroyuki Hirokawa
  • , Kenji Sogawa
  • , Tsuneaki Omae
  • , Akihiro Ishibazawa
  • , Shoji Kishi
  • , Hideo Akiyama
  • , Hidetaka Matsumoto
  • , Ryo Mukai
  • , Masahiro Morimoto
  • , Mitsuru Nakazawa
  • , Yukihiko Suzuki
  • , Takashi Kudo
  • , Kobu Adachi
  • , Susumu Ishida
  • , Kousuke Noda
  • , Satoru Kase
  • , Shohei Mori
  • , Ryo Ando
  • , Michiyuki Saito
  • , Tomohiro Suzuki
  • , Kanji Takahashi
  • , Yoshimi Nagai
  • , Tadashi Nakauchi
  • , Haruhiko Yamada
  • , Shunji Kusaka
  • , Daishi Tsujioka
  • , Akitaka Tsujikawa
  • , Kiyoshi Suzuma
  • , Tatsuro Ishibashi
  • , Koh-Hei Sonoda
  • , Yasuhiro Ikeda
  • , Riichiro Kohno
  • , Keijiro Ishikawa
  • , Mineo Kondo
  • , Maki Kozawa
  • , Takashi Kitaoka
  • , Eiko Tsuiki
  • , Yuichiro Ogura
  • , Munenori Yoshida
  • , Hiroshi Morita
  • , Aki Kato
  • , Yoshio Hirano
  • , Kazuhiko Sugitani
  • , Hiroko Terasaki
  • , Takeshi Iwase
  • , Yasuki Ito
  • , Shinji Ueno
  • , Hiroki Kaneko
  • , Norie Nonobe
  • , Taro Kominami
  • , Noriyuki Azuma
  • , Tadashi Yokoi
  • , Hiroyuki Shimada
  • , Hiroyuki Nakashizuka
  • , Takayuki Hattori
  • , Ari Shinojima
  • , Yorihisa Kitagawa
  • , Fumio Shiraga
  • , Yuki Morizane
  • , Shuhei Kimura
  • , Tsunehiko Ikeda
  • , Teruyo Kida
  • , Takaki Sato
  • , Masanori Fukumoto
  • , Kazuyuki Emi
  • , Hiroshi Nakashima
  • , Shinobu Takeuchi
  • , Sumiyoshi Tanaka
  • , Tomohiro Iida
  • , Hideki Koizumi
  • , Ichiro Maruko
  • , Taiji Hasegawa
  • , Akiko Kogure
  • , Hiroyuki Iijima
  • , Tomohiro Oshiro
  • , Yasushi Tateno
  • , Wataru Kikushima
  • , Atsushi Sugiyama
  • , Seigo Yoneyama
  • , Kazuaki Kadonosono
  • , Shimpei Sato
  •  & Shin Yamane

Corresponding author

Correspondence to Shumpei Obata.

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Conflicts of interest

S. Obata, None; O. Sawada, None; M. Kakinoki, None; R. Matsumoto, None; Y. Saishin, None; M. Ohji, None.

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Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Corresponding Author: Shumpei Obata

Members of the Japan-Retinal Detachment Registry Group are listed in the Acknowledgements section.

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Obata, S., Sawada, O., Kakinoki, M. et al. Effects of internal limiting membrane peeling on anatomical and functional outcomes in macula-off rhegmatogenous retinal detachment complicated by proliferative vitreoretinopathy: Japan-Retinal Detachment Registry. Jpn J Ophthalmol 67, 417–423 (2023). https://doi.org/10.1007/s10384-023-01000-y

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  • DOI: https://doi.org/10.1007/s10384-023-01000-y

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