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Subtype prevalence and baseline visual acuity by age in Japanese patients with neovascular age-related macular degeneration

  • Clinical Investigation
  • Published:
Japanese Journal of Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To investigate age-specific prevalence of disease subtypes and baseline best-corrected visual acuity (BCVA) in Japanese patients with treatment-naïve neovascular age-related macular degeneration (nAMD).

Study design

Retrospective multicenter case series.

Methods

We reviewed the records of patients with treatment-naïve nAMD who underwent initial treatment in 14 institutions in Japan sometime during the period from 2006 to 2015. In patients in whom both eyes were treated, only the eye treated first was included for analysis. The patients were stratified by age for the analysis.

Results

In total, 3096 eyes were included. The overall prevalence of subtypes was as follows: typical AMD, 52.6%; polypoidal choroidal vasculopathy (PCV), 42.8%; retinal angiomatous proliferation (RAP), 4.6%. The number of eyes in each age group was as follows: younger than 60 years, 199; 60s, 747; 70s, 1308; 80s, 784; 90 years or older, 58. The prevalence of typical AMD in each age group was 51.8%, 48.1%, 52.1%, 57.7%, and 55.2%, respectively. The prevalence of PCV was 46.7%, 49.1%, 44.7%, 34.4%, and 19.0%, respectively. The prevalence of RAP was 1.5%, 2.8%, 3.2%, 7.9%, and 25.9%, respectively. The prevalence of PCV decreased with age, whilst that of RAP increased. The prevalence of RAP was higher than that of PCV in patients aged 90 years or older. The mean baseline BCVA (logMAR) was 0.53. In each age group, the mean baseline BCVA was 0.35, 0.45, 0.54, 0.62, and 0.88, respectively. The mean logMAR BCVA at baseline significantly worsened with age (P < 0.001).

Conclusion

The prevalence of nAMD subtypes differed according to age in Japanese patients. The baseline BCVA worsened with age.

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Acknowledgements

We thank Edanz (https://jp.edanz.com/ac) for editing a draft of this manuscript.

Author information

Authors and Affiliations

  1. Department of Ophthalmology, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga, 520-2192, Japan

    Tomoko Sawada & Masahito Ohji

  2. Department of Ophthalmology, Nagoya City University, Aichi, Japan

    Tsutomu Yasukawa

  3. Department of Ophthalmology, Sapporo City General Hospital, Hokkaido, Japan

    Hiroko Imaizumi

  4. Department of Ophthalmology, Mie University, Mie, Japan

    Hisashi Matsubara

  5. Department of Ophthalmology, Yamaguchi University, Yamaguchi, Japan

    Kazuhiro Kimura

  6. Department of Ophthalmology, Kagoshima University, Kagoshima, Japan

    Hiroto Terasaki

  7. Department of Ophthalmology, Hyogo College of Medicine, Hyogo, Japan

    Hiroto Ishikawa

  8. Department of Ophthalmology, University of Tsukuba, Ibaraki, Japan

    Tomoya Murakami

  9. Department of Ophthalmology, National Defense Medical College, Saitama, Japan

    Masaru Takeuchi

  10. Department of Ophthalmology, Tokushima University, Tokushima, Japan

    Yoshinori Mitamura

  11. Department of Ophthalmology, Nara Medical University, Nara, Japan

    Yutaro Mizusawa

  12. Department of Ophthalmology, University of Fukui, Fukui, Japan

    Yoshihiro Takamura

  13. Department of Ophthalmology, Shinshu University, Nagano, Japan

    Toshinori Murata

  14. Department of Ophthalmology, St. Marianna University School of Medicine, Kanagawa, Japan

    Jiro Kogo

  15. J-CREST (Japan Clinical Retinal Study Team) Study Group, Tokyo, Japan

    Tomoko Sawada, Tsutomu Yasukawa, Hiroko Imaizumi, Hisashi Matsubara, Kazuhiro Kimura, Hiroto Terasaki, Hiroto Ishikawa, Tomoya Murakami, Masaru Takeuchi, Yoshinori Mitamura, Yutaro Mizusawa, Yoshihiro Takamura, Toshinori Murata, Jiro Kogo & Masahito Ohji

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  1. Tomoko Sawada
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Corresponding author

Correspondence to Tomoko Sawada.

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Conflicts of interest

T. Sawada, Grants or contracts (Alcon), Payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events (Bayer, Senju, Novartis, Chugai); T. Yasukawa, Honoraria for seminar (Novartis, Bayer, Santen); H. Imaizumi, Payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events (Novartis, Torii, Santen, Sumitomo, Bayer); H. Matsubara, None; K. Kimura, None; H. Terasaki, None; H. Ishikawa, None; T. Murakami, None; M. Takeuchi, None; Y. Mitamura, Grants or contracts (Santen), Payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events (Santen, Bayer, Novartis); Y. Mizusawa, None; Y. Takamura, None; T. Murata, None; J. Kogo, None; M. Ohji, Grants or contracts (Santen, Alcon, Otsuka, HOYA, AMO, Bayer, Novartis), Consulting fees (Alcon, Bayer), Payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events (Novartis, Bayer, Chugai, Santen, Alcon, Boehringer-Ingelheim, Otsuka).

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Corresponding Author: Tomoko Sawada

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Sawada, T., Yasukawa, T., Imaizumi, H. et al. Subtype prevalence and baseline visual acuity by age in Japanese patients with neovascular age-related macular degeneration. Jpn J Ophthalmol 67, 149–155 (2023). https://doi.org/10.1007/s10384-023-00981-0

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  • DOI: https://doi.org/10.1007/s10384-023-00981-0

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