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Pathological findings of multifocal choroiditis with panuveitis and punctate inner choroidopathy

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Abstract

Purpose

To compare the pathological findings between multifocal choroiditis with panuveitis (MCP) and punctate inner choroidopathy (PIC).

Methods

Fourteen eyes of 14 patients clinically diagnosed as having MCP or PIC who underwent surgical excision of choroidal neovascularization (CNV) were studied. Immunohistochemical findings of the excised CNV in MCP (eight eyes) and PIC (six eyes) cases were compared. Antibodies against vascular endothelial growth factor (VEGF), CD68, CD3, and CD20 were used as primary antibodies.

Results

Expression of VEGF and CD68 in the CNV was observed in all MCF and PIC cases. In three of eight eyes with MCP, intraocular inflammatory findings were found clinically, while immunohistochemical study demonstrated infiltration of CD20-positive B lymphocytes in the CNV. No B lymphocyte infiltration was found in the six eyes with PIC. No differences in pathological findings were found between the five MCP eyes without intraocular inflammation and the six PIC eyes, with all eyes showing no B lymphocyte infiltration.

Conclusions

In MPC cases showing clinical inflammatory findings, infiltration of B lymphocytes was also observed histopathologically, suggesting that the presence of inflammatory cells in the anterior chamber or vitreous body clinically is an indicator of active inflammatory CNV. However, this study clarifies that MCP eyes without intraocular inflammation and PIC eyes are not different in histopathological findings.

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Authors and Affiliations

  1. Department of Ophthalmology, School of Medicine, Nihon University, Tokyo, Japan

    Hiroyuki Shimada, Mitsuko Yuzawa, Tokihito Hirose, Hiroyuki Nakashizuka, Takayuki Hattori & Yoko Kazato

Authors
  1. Hiroyuki Shimada
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  2. Mitsuko Yuzawa
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  3. Tokihito Hirose
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  4. Hiroyuki Nakashizuka
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  5. Takayuki Hattori
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  6. Yoko Kazato
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Corresponding author

Correspondence to Hiroyuki Shimada.

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Shimada, H., Yuzawa, M., Hirose, T. et al. Pathological findings of multifocal choroiditis with panuveitis and punctate inner choroidopathy. Jpn J Ophthalmol 52, 282–288 (2008). https://doi.org/10.1007/s10384-008-0566-2

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  • DOI: https://doi.org/10.1007/s10384-008-0566-2

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